Status:
ACTIVE_NOT_RECRUITING
The Impact of Targeted Temperature Management Duration on Thrombin Function in Cardiac Arrest Patients
Lead Sponsor:
Tang Ziren
Conditions:
Targeted Temperature Management
Cardiac Arrest
Eligibility:
All Genders
18-80 years
Phase:
NA
Brief Summary
This study will be a single-center, prospective, randomized controlled trial with an estimated sample size of 64 patients. Eligible patients will be randomly assigned in a 1:1 ratio to receive TTM for...
Eligibility Criteria
Inclusion
- age between 18 and 80 years;
- Glasgow Coma Scale score of less than 8 upon admission;
- patients resuscitated after out-of-hospital cardiac arrest; and (4) patient or their legal representative has signed the informed consent form.
Exclusion
- cardiac arrest caused by irreversible factors such as trauma or poisoning;
- cardiac arrest due to terminal conditions like advanced cancer;
- uncorrected persistent cardiogenic shock, defined as a systolic blood pressure below 90 mmHg despite treatment with fluid resuscitation, vasopressors, and inotropic agents;
- pre-existing cerebrovascular disease or CT-confirmed intracerebral hemorrhage upon admission;
- pre-arrest Cerebral Performance Category (CPC) score between 3 and 5;
- bradycardia or sick sinus syndrome following the return of spontaneous circulation;
- pre-existing coagulation disorders or severe bleeding tendencies;
- pregnant or breastfeeding women, or women of childbearing age with elevated serum hCG levels;
- presence of treatment limitations (such as refusal by the patient or legal representative to undergo advanced life support, including mechanical ventilation, chest compressions, or targeted temperature management);
- determination by the principal investigator that the patient is unsuitable for the trial.
Key Trial Info
Start Date :
December 1 2024
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 31 2025
Estimated Enrollment :
64 Patients enrolled
Trial Details
Trial ID
NCT06543849
Start Date
December 1 2024
End Date
December 31 2025
Last Update
April 11 2025
Active Locations (1)
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1
Beijing chao-yang Hospital, Capital Medical University
Beijing, Beijing Municipality, China