Status:
RECRUITING
Evaluation of Periapical Healing Following Endodontic Microsurgery With Leukocyte and Platelet Rich Fibrin (L-PRF)
Lead Sponsor:
University of Pennsylvania
Conditions:
Apical Periodontitis
Eligibility:
All Genders
18+ years
Brief Summary
The purpose of the study is to evaluate peri-radicular healing after root-end surgery using Leukocyte and Platelet Rich Fibrin. The study population includes patients diagnosed with persistent periapi...
Eligibility Criteria
Inclusion
- Provision of signed and dated informed consent form.
- Stated willingness to comply with all study procedures and availability for the duration of the study, including the follow-up visits.
- Male or Female age \>18 years old.
- In good general health (ASA 2 or less) with no contraindications for Endodontic Microsurgery.
- Persistent endodontic periapical pathology Class A, B, or C according to the Kim and Kratchman classification (5)
- Intact coronal restorations with no evidence of leakage or caries under the restoration.
Exclusion
- Minors.
- Suspected root fractures.
- ASA classification 3 or greater.
- Periapical pathology Class D, E, or F according to the Kim and Kratchman classification (5).
- Patients with history of Oral or IV Bisphosphonate use.
- Patients may be excluded if their treatment team do not believe Endodontic microsurgery and L-PRF graft is in the patient's best interests.
Key Trial Info
Start Date :
August 1 2024
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
June 30 2026
Estimated Enrollment :
50 Patients enrolled
Trial Details
Trial ID
NCT06545084
Start Date
August 1 2024
End Date
June 30 2026
Last Update
August 27 2025
Active Locations (1)
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1
Penn Dental Medicine
Philadelphia, Pennsylvania, United States, 19104