Status:
RECRUITING
Distinct Exercise Modalities on Gut Microbiome
Lead Sponsor:
Faculty of Sports- Research Center in Physical Activity, Health and Leisure
Collaborating Sponsors:
Unit for Multidisciplinary Research in Biomedicine
Conditions:
Sarcopenia
Older Adults
Eligibility:
All Genders
60+ years
Phase:
NA
Brief Summary
Sarcopenia is a multifactorial muscular disease with detrimental clinical consequences, impairing physical function, functional independence, quality of life, need for long-term care and premature mor...
Detailed Description
The gut microbiome is an important regulator of metabolism and has recently emerged as a relevant contributor to musculoskeletal health and disease, specifically to changes in skeletal muscle mass and...
Eligibility Criteria
Inclusion
- Age: ≥ 60 years old
- Sex: Men and women
- Medical History: Objective indicators of sarcopenia- Handgrip strength: men \< 27 kg and women \< 16 kg; 4-m gait speed ≤ 0.8 m/s; Short Physical Performance Battery ≤ 8-point score; Chair stand test \> 15 s; Time-up-go ≥ 20 s.
- Physical Inactivity: International Physical Activity Questionnaire (IPAQ)- Portuguese version ≤ 150 minutes/week of moderate physical activity
- Willingness to participate in all study procedures regardless of possible group allocation.
Exclusion
- Failure to provide consent.
- Uncontrolled Hypertension: SBP\> 180 mmHg or DBP\> 110 mmHg.
- History of coronary artery stenosis (\>50%).
- Heart Failure: Ejection fraction \< 50%.
- History of syncope at exertion.
- History of hypertrophic cardiomyopathy, arrhythmogenic cardiomyopathy, dilated cardiomyopathy or evidence in the previous 6 months of myocarditis or pericarditis.
- Severe valvular heart disease.
- Chronic kidney disease stage ≥ 4,8.
- Chronic Obstructive Pulmonary Disease stage ≥ 3,9.
- Musculoskeletal or neurodegenerative conditions that hinder exercise engagement.
- Current participation in another structured exercise training program.
- Inability to commit to study procedures or the exercise intervention throughout the study period.
- Other condition or concern precluding safe participation.
Key Trial Info
Start Date :
September 1 2024
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 30 2026
Estimated Enrollment :
69 Patients enrolled
Trial Details
Trial ID
NCT06545123
Start Date
September 1 2024
End Date
December 30 2026
Last Update
March 4 2025
Active Locations (1)
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1
Faculty of Sports
Porto, Portugal