Status:
RECRUITING
Rapid Eye Movement Restoration and Enhancement for Sleep-deprived Trauma-adaptation
Lead Sponsor:
University of Wisconsin, Madison
Collaborating Sponsors:
United States Department of Defense
Conditions:
Healthy Volunteers
Eligibility:
All Genders
18-50 years
Phase:
NA
Brief Summary
The goal of this clinical trial is to find out whether stimulating the brain with electrical current during naps can increase certain kinds of brain activity that happen during sleep and lead to impro...
Detailed Description
This is a single-blind, two-phase study. In the first phase, each participant will be assigned a nap length, a trigger region, a stimulation type (difference frequency, multipolar transcranial electri...
Eligibility Criteria
Inclusion
- Adults aged 18-50 years
- Medically healthy
- English-speaking (able to provide consent and complete questionnaires)
- Citizen or holding permanent resident status
- Regular napper (1 or more naps per week)
Exclusion
- Any current or past history of neurological disorders or acquired neurological disease (e.g. stroke, traumatic brain injury), including intracranial lesions
- History or head trauma resulting in prolonged loss of consciousness; or a history of \>3 grade 1 concussions
- Current history of poorly controlled headaches including intractable or poorly controlled migraines
- Any systemic illness or unstable medical condition that may cause a medical emergency in case of a provoked seizure (cardiac malformation, cardiac dysrhythmia, asthma, etc)
- History of seizures, diagnosis of epilepsy, histoy of abnormal (epileptiform) EEG, or family history of treatment resistant epilepsy with the exception of a single seizure of benign etiology (e.g. febrile seizures) in the judgment of a board-certified neurologist
- Possible pregnancy or plan to become pregnant in the next 6 months
- Any metal in the body
- Any medical devices or implants (i.e. cardiac pacemaker, medication infusion pump, cochlear implant, vagal nerve stimulator) unless otherwise approved by the responsible MD
- Dental implants containing metal
- Any medication that may alter seizure threshold: ADHD stimulants (Adderall, amphetamine); tricyclic/stypical antidepressants (amitriptyline, doxepine, imipramine, maprotiline, nortriptyline, buproprion); antipsychotics (chlorpromazine, clozapine); bronchodilators (theophylline, aminophylline); antibiotics (fluoroquinolones, imipenem, penicillin, cephalosporins, metronidazole, isoniazid); Antivirals (valacyclovir, ritonavir); OTC antihistamines (diphenhydramine, Benadryl)
- Claustrophobia (a fear of small or closed places)
- Back problems that would prevent lying flat for up to two hours
- Regular night-shift work (second or third shift)
Key Trial Info
Start Date :
July 10 2024
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
February 1 2026
Estimated Enrollment :
80 Patients enrolled
Trial Details
Trial ID
NCT06547086
Start Date
July 10 2024
End Date
February 1 2026
Last Update
July 31 2025
Active Locations (1)
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1
University of Wisconsin
Madison, Wisconsin, United States, 53719