Status:
COMPLETED
Intermittent Theta Burst Stimulation on Anhedonia in Depression
Lead Sponsor:
Anhui Medical University
Conditions:
Depression
Electroencephalography
Eligibility:
All Genders
16-50 years
Phase:
NA
Brief Summary
Study comparing the efficacy of two TMS patterns (intermittent theta-burst stimulation, iTBS, and repetitive transcranial magnetic stimulation, rTMS) in treating anhedonia and their associated brain n...
Detailed Description
Anhedonia is a core feature in major depressive disorders, severely affecting up to 70% patients and remaining untreated after traditional antidepressants therapies. In previous work, the investigator...
Eligibility Criteria
Inclusion
- diagnosed by more than two clinical psychiatrists, using the DSM-5 diagnostic criteria for depression.
- the Self-Report Apathy Evaluation Scale score was more than 37 and the The Temporal Experience of Pleasure Scale score was less than 76.
- consistent medical therapeutic plan for ≥4 weeks or no history of antidepressant drugs before rTMS treatment.
- aged between 16 and 50 years old.
Exclusion
- participants with unstable physical conditions, pregnancy or those that were breastfeeding.
- metal implants on or inside the head. increased intracranial pressure from cerebral infarction or brain injury. a history of substance abuse or major psychiatric diseases other than depression and current use of psychoactive drug.
Key Trial Info
Start Date :
August 12 2020
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 14 2022
Estimated Enrollment :
33 Patients enrolled
Trial Details
Trial ID
NCT06552026
Start Date
August 12 2020
End Date
December 14 2022
Last Update
August 13 2024
Active Locations (1)
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1
Anhui Medical University
Hefei, Anhui, China, 230032