Status:
NOT_YET_RECRUITING
Identification of Serum Level of Glutathione Peroxidase 4
Lead Sponsor:
Assiut University
Conditions:
Spondyloarthropathy
Eligibility:
All Genders
18-85 years
Brief Summary
* Analysis of the level of glutathione peroxidase 4 (GPX4) in ankylosing spondylitis and axial psoriatic arthritis patients. * The association of glutathione peroxidase 4 (GPX4) with disease activity ...
Detailed Description
Ferroptosis, first reported by Dixon et al. in 2012, is a form of non-apoptotic cell death driven by iron-dependent lipid reactive oxygen species (ROS) and accelerated by the accumulation of lipid per...
Eligibility Criteria
Inclusion
- Patients diagnosed as ankylosing spondylitis according to ASAS criteria . \[13\]
- Patients diagnosed as psoriatic arthritis according to CASPAR criteria. \[14\]
- Age (\>18).
Exclusion
- Patient with other autoimmune Rheumatic diseases.
- patients with any of the following conditions: I) severe liver and kidney dysfunction; II) hematopoietic diseases; III) infectious diseases; IV) tumors; or V) other wasting diseases. \[15\]
- patients received certain drugs (for example, sulfasalazine, artemisinin, statins), and experimental reagents (such as erastin) .\[16\]
Key Trial Info
Start Date :
September 1 2024
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
July 1 2027
Estimated Enrollment :
85 Patients enrolled
Trial Details
Trial ID
NCT06554392
Start Date
September 1 2024
End Date
July 1 2027
Last Update
August 15 2024
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