Status:
COMPLETED
MicroRNAs and Prognosis in Breast Cancer
Lead Sponsor:
Casa Sollievo della Sofferenza IRCCS
Conditions:
Breast Cancer Female
Metastases Breast
Eligibility:
FEMALE
18+ years
Brief Summary
Mono-centric, observational retrospective and prospective study, designed for breast cancer patients to identify novel miRNA based biomarker able to predict metastases development in breast cancer pat...
Detailed Description
The potential role of miRNAs will be studied as a predictor of metastases development. miRNAs expression and miRNAs promoter methylation will be evaluated in surgically removed specimens obtained from...
Eligibility Criteria
Inclusion
- Retrospective Cohort
- Tissue samples from breast cancer cases diagnosed from 2004 to 2014 for which informed consent for tumour banking and complete clinicopathological and follow up data were available.
Exclusion
- Pre-surgery neoadjuvant treatment for breast cancer with chemotherapy, lapatinib, trastuzumab, letrozole, anastrozole, exemestane or tamoxifen.
- Other cancers diagnosed in the last five years.
- Prospective Cohort:
- Inclusion Criteria:
- Ability to provide written informed consent; Age greater than 18 years; Histological diagnosis of Breast disease; First diagnosis of Breast Cancer; Syncronous distant metastasis absent.
Key Trial Info
Start Date :
October 28 2014
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
November 28 2019
Estimated Enrollment :
1432 Patients enrolled
Trial Details
Trial ID
NCT06555354
Start Date
October 28 2014
End Date
November 28 2019
Last Update
August 15 2024
Active Locations (1)
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1
Casa sollievo della Sofferenza IRCCS
San Giovanni Rotondo, FG, Italy, 71013