Status:
RECRUITING
Risk Factors of Extubation Failure in PICU Patients
Lead Sponsor:
Sohag University
Conditions:
Extubation Failure
Eligibility:
All Genders
30-18 years
Brief Summary
Up to 20% of MV patients experience EF \[10\]. EF is defined as the need to reinsert the endotracheal tube to resume MV in patients extubated for less than 48 hours. It has high rates of morbidity and...
Detailed Description
Mechanical ventilation (MV) is a common life support modality in 40% of pediatric intensive care unit (PICU) patients. The process of ventilatory support follows a continuum of care, beginning with th...
Eligibility Criteria
Inclusion
- All patient at PICU \< 18 years subjected to MV through an endotracheal tube at least \>12 hours.
- Patients eligible for weaning from MV according to the weaning criteria (Evidence for some reversal of the underlying cause following for respiratory failure, Adequate oxygenation" PaO2/FIO2 ratio ≥ 200, FIO2 ≤ 0.40, PaO2 ≥ 60, PaCO2 ≤ 60 and PEEP ≤ 5 cmH2O.", PH ≥ 7.25, Respiratory rate (RR) ≤ 45 bpm, Heart rate (HR) ≤ 140 bpm,(rapid shallow breathing index = tidal volume / RR) RSBI ≤ 8 breaths/min/ml/kg body weight, Hemodynamic stable, no or minimal vasopressor or inotropes"\[1,12\],.
- Appropriate level of consciousness, No continuous sedation infusion nor neuromuscular blocking agents, afebrile, adequate hemoglobin ≥ 7.5 g/dl and/or no evidence of hemorrhage.
Exclusion
- Patients less than 30 days.
- Tracheostomized patients.
- Death on mv ≤ 12 hours.
- Unplanned extubation.
Key Trial Info
Start Date :
May 1 2024
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
May 1 2025
Estimated Enrollment :
100 Patients enrolled
Trial Details
Trial ID
NCT06557941
Start Date
May 1 2024
End Date
May 1 2025
Last Update
August 16 2024
Active Locations (1)
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1
Sohag University Hospitals
Sohag, Egypt