Status:
RECRUITING
Effectiveness of Gut Microbiota-targeted Diatery Intervention Among Older People Living With HIV
Lead Sponsor:
Fudan University
Conditions:
Hiv
Atherosclerosis
Eligibility:
All Genders
40+ years
Phase:
NA
Brief Summary
The goal of this clinical trial is to conduct a dietary intervention targeting HIV specific gut microbiota alterations for primary atherosclerotic cardiovascular disease (ASCVD) prevention and evaluat...
Detailed Description
The investigators utilize a pragmatic randomized controlled trial design to evaluate the effectiveness of dietary intervention in real-world conditions, without strict control, thereby enhancing the g...
Eligibility Criteria
Inclusion
- HIV-infected patients diagnosed according to the diagnostic criteria of China AIDS diagnosis and treatment guidelines;
- Aged 40 years and above;
- at risk of CVD: having any two of those risk factors: dyslipidemia, DM or elevated blood glucose, smoking, hypertention or elevated blood pressure, metabolic syndrome,overweight/obesity; or PCE score\>5%,
- Those with a predicted survival time of \>1 year;
- No plans to leave the depth in the next 3 months;
- Voluntary participation in this study and signing the informed consent
Exclusion
- Those with a previous history of CVD;
- Those with HIV-related neurocognitive impairment, Alzheimer's disease or dementia, and a variety of serious opportunistic infections;
- Currently suffering from malignant tumors, gastrointestinal diseases; People with an aversion to eating;
- Allergic to nuts and fish;
- People who take medicinal calcium \>1000 mg per day or omega-3 supplements;
- Plan to become pregnant within 6 months;
- Are participating in other HIV-related or dietary intervention-related scientific research programs.
Key Trial Info
Start Date :
August 20 2024
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
May 20 2025
Estimated Enrollment :
110 Patients enrolled
Trial Details
Trial ID
NCT06560840
Start Date
August 20 2024
End Date
May 20 2025
Last Update
September 26 2024
Active Locations (1)
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1
The Third People's Hospital of Shenzhen
Shenzhen, China