Status:
COMPLETED
Fecal Microbiota and Monocyte Trained Immunity in CHD Patients With Different hsCRP
Lead Sponsor:
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Conditions:
Coronary Heart Disease
Unstable Angina
Eligibility:
All Genders
35-75 years
Brief Summary
This single-center study enrolled patients aged 35-75 years who were diagnosed with unstable angina (UA), and had at least one of the three major coronary arteries with a ≥ 50% reduction in lumen diam...
Detailed Description
This single-center study enrolled patients aged 35-75 years who were diagnosed with unstable angina (UA), and had at least one of the three major coronary arteries with a ≥ 50% reduction in lumen diam...
Eligibility Criteria
Inclusion
- Age \>35 and \<75 years
- Admitted for UA and had at least one of the three major coronary arteries with ≥50% reduction in lumen diameter by angiographic visual estimation
- Informed consent obtained
Exclusion
- Prior myocardial infarction
- Left ventricular ejection fraction ≤ 40% on echocardiography
- Have a history of malignancies, auto-immune, auto-inflammatory disease or on immunomodulatory medication
- Ongoing acute, chronic, or concurrent infectious disease
- Surgery 3 months before sample collection
- Immunization with a vaccine within 4 weeks before sample collection
- Pregnancy, or breast feeding
- History of primary or secondary immunodeficiency
- Renal failure with estimated glomerular filtration rate (eGFR) \< 60 mL/min/1.73m2
- Active liver disease with alanine aminotransferase (ALT \>80 U/L) or aspartate aminotransferase (AST \> 80 U/L)
- History of chronic obstructive pulmonary disease (COPD)
- Refuse to provide written consent
- Any other circumstances in which the investigator judges that the patient is not suitable
Key Trial Info
Start Date :
May 11 2021
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
July 15 2024
Estimated Enrollment :
100 Patients enrolled
Trial Details
Trial ID
NCT06562309
Start Date
May 11 2021
End Date
July 15 2024
Last Update
August 20 2024
Active Locations (1)
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1
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Wuhan, Hubei, China