Status:
COMPLETED
Intra-arterial Cisplatin Plus Rh-endostatin Combined With Systematic Chemotherapy in Osteosarcoma
Lead Sponsor:
Shanghai 6th People's Hospital
Conditions:
Osteosarcoma
Bone Cancer
Eligibility:
All Genders
12+ years
Phase:
PHASE1
PHASE2
Brief Summary
The goal of this clinical trial is to learn the efficacy and safety of intra-arterial cisplatin plus anti-angiogenesis inhibitor rh-endostatin (Endostar) combined with systematic chemotherapy in osteo...
Detailed Description
Osteosarcoma (OS) is the most common bone cancer in children and young adolescents. Despite the emergence of new therapeutic modalities such as targeted therapy and immunotherapy, chemotherapy remains...
Eligibility Criteria
Inclusion
- Histologically or cytologically confirmed diagnosis of osteosarcoma patients aged 12-40 years old;
- Accept to receive treatment with neoadjuvant chemotherapy regimen and completing the standard treatment course; Voluntary informed consent, joining the study with good compliance.
- Have detailed medical data (such as medical history data, laboratory reports of blood routine and liver and kidney functions, pathology reports, etc.), and complete records of postoperative follow-up.
Exclusion
- Combined history of acute injury, infection and surgery in the last 3 months;
- Those with severe liver and kidney function abnormalities;
- Those who are using anti-inflammatory drugs;
- Pre-existing hematologic diseases before treatment;
- Combined with other malignant tumors;
- Diagnosed with autoimmune disease or using steroid drugs for more than 1 month before treatment;
- Suffering from mental illness or cognitive dysfunction.
Key Trial Info
Start Date :
December 3 2024
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 20 2025
Estimated Enrollment :
10 Patients enrolled
Trial Details
Trial ID
NCT06562673
Start Date
December 3 2024
End Date
July 20 2025
Last Update
December 29 2025
Active Locations (1)
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1
Shanghai Jiao Tong University School of Medicine, Shanghai Sixth People's Hospital,
Shanghai, China, 200233