Status:
RECRUITING
Effect of Transcranial Alternating Current Stimulation(tACS) for Early Alzheimer's Disease
Lead Sponsor:
Anhui Medical University
Conditions:
Transcranial Alternating Current Stimulation
Electroencephalography
Eligibility:
All Genders
50-85 years
Phase:
NA
Brief Summary
To investigate the clinical effect neural mechanism of transcranial alternating current stimulation in early Alzheimer's disease
Detailed Description
Upon meeting the inclusion criteria and providing informed consent, each participant will complete a series of cognitive assessments and tACS at the First Affiliated Hospital of Anhui medical universi...
Eligibility Criteria
Inclusion
- Subject diagnosed with early Alzheimer's disease or related diseases according to NIA-AA criteria.
- Subjects must have a MMSE score between 10 and 27,indicating mild cognitive impairment or dementia.
- CDR score ≤ 2.
- Subject under treatment by IAChE for at least 3 months.
- psychotropic treatments are tolerated if they were administered and unchanged for at least 3 months.
Exclusion
- CDR \> 2
- Any history or clinical signs of other severe psychiatric illnesses (like major depression,psychosis or obsessive compulsive disorder).
- History of head injury,stroke,or other neurologic disease.
- Organic brain defects on T1 or T2 images.
- History of seizures or unexplained loss of consciousness.
- Implanted pacemaker,medication pump,vagal stimulator,deep brain stimulator.
- Family history of medication refractory epilepsy.
- History of substance abuse within the last 6 months.
Key Trial Info
Start Date :
March 1 2024
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
July 1 2026
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT06565143
Start Date
March 1 2024
End Date
July 1 2026
Last Update
August 21 2024
Active Locations (1)
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1
Anhui Medical University
Hefei, Anhui, China, 230032