Status:
COMPLETED
Effect of Remazolam on Hemodynamics During Hepatectomy
Lead Sponsor:
Jun Zhang
Conditions:
Hemodynamic Instability
Eligibility:
All Genders
18+ years
Phase:
PHASE4
Brief Summary
There is high incidence of hemodynamic instability in patients undergoing hepatectomy with low central venous pressure, especially in general anesthesia combined with epidural anesthesia. Remazolam, a...
Detailed Description
Investigators plan to adopt the following strategies in the clinical study of this project: (1) To compare remazolam and propofol during anesthetic induction and maintenance; (2) Remazolam group: rema...
Eligibility Criteria
Inclusion
- Patients who sign informed consent and are willing to complete the study according to the plan;
- Over 18 years of age;
- ASA grade Ⅰ \~ Ⅲ;
- Elective surgery;
- General anesthesia combined with epidural anesthesia;
- Child Pugh is classified as Level A
Exclusion
- Abnormal coagulation function;
- Abnormal platelet;
- A history of drug dependence;
- Neurological diseases;
- Severe sinus bradycardia (HR\<50 beats/min);
- Atrial fibrillation;
- Systolic blood pressure ≥200mmHg and/or diastolic blood pressure ≥120mmHg.
- Cardiac insufficiency.
- Child Pugh is classified as B or C.
Key Trial Info
Start Date :
August 23 2024
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
November 8 2024
Estimated Enrollment :
70 Patients enrolled
Trial Details
Trial ID
NCT06565715
Start Date
August 23 2024
End Date
November 8 2024
Last Update
March 18 2025
Active Locations (1)
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1
Fudan University Shanghai Cancer Center
Shanghai, China