Status:
RECRUITING
Study of Autologous Tumor-Infiltrating Lymphocytes in Pediatric, Adolescent, and Young Adult Participants
Lead Sponsor:
Iovance Biotherapeutics, Inc.
Conditions:
Soft Tissue Sarcoma
Primary Central Nervous System Carcinoma
Eligibility:
All Genders
6-21 years
Phase:
PHASE1
Brief Summary
This study is planned to test the safety and tolerability of the TIL regimen. The study will also test how well TIL fights cancer. The study will enroll children, teenagers, and young adults with soli...
Eligibility Criteria
Inclusion
- Participant is ≥ 8 kg and ≤ 21 years of age at the time of informed consent and assent.
- Histologically or cytologically confirmed recurrent or refractory solid tumor (Rhabdomyosarcoma, Ewing sarcoma, primary CNS malignancies, melanoma) after standard therapy which has failed all available curative therapy.
- Acceptable performance status and an estimated life expectancy of \> 6 months.
- At least one resectable lesion (solitary or aggregate lesions) for TIL generation.
- Following tumor resection for TIL generation, the participant will have at least one remaining measurable lesion for response assessment.
- Preplanned surgical procedure(s) will take place at least 14 days (for major operative procedures) prior to the tumor resection.
- All prior anticancer treatment-related AEs should be recovered, exceptions are peripheral neuropathy, alopecia, vitiligo, or medically controlled endocrine dysfunction.
- Agreement to abide by the protocol indicated contraception use, including refraining from donating sperm or eggs (ova, oocytes), as appropriate for the age and sexual activity of pediatric, adolescent, and young adult participants and as required by local regulations.
- Signed informed consent and assent when applicable.
- Written authorization for use and disclosure of protected health information.
- Ability to adhere to the study visit schedule and other protocol requirements.
- Acceptable hematologic parameters.
- Adequate organ function.
- Modified Ross criteria class 1 and an LVFS \> 25% or an LVEF ≥ 50%.
- Adequate pulmonary function.
- Participant and/or the legal guardian who provided consent is willing for the participant to receive optimal supportive care.
- A legal guardian or primary caregiver must be available to help the study-site personnel ensure follow-up and accompany the participant to the study site on each assessment day according to the SoA.
Exclusion
- Participant with a non-CNS tumor has symptomatic untreated brain metastases and/or carcinomatous meningitis.
- Participant has an active or uncontrolled intercurrent illness(es) that would pose increased risks for study participation.
- Participants are not eligible if they experience uncontrolled seizures.
- Participants with history of intracranial hemorrhage/spinal cord hemorrhage.
- Participant has active uveitis that requires active treatment.
- Participant has significant psychiatric disease or substance abuse in the investigator's opinion that would prevent adequate informed consent.
- Participant has any form of primary or acquired immunodeficiency.
- History of clinically significant chronic obstructive pulmonary disease, asthma, interstitial lung disease, or other chronic lung disease.
- History of hypersensitivity reaction to any components of the study intervention.
- Any other condition that in the investigator's judgment would significantly increase the risks of participation.
- Any complication or delayed healing from an excisional procedure that in the investigator's opinion would increase the risks of participation.
- Another primary malignancy within the previous 3 years.
- History of allogeneic cell or organ transplant.
- Requiring systemic steroid therapy higher than the physiologic replacement dose.
- Received or will receive a live or attenuated vaccination within 28 days prior to the start of the NMA-LD.
- Any active viral, bacterial, or fungal infection requiring ongoing systemic treatment.
Key Trial Info
Start Date :
March 28 2024
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
July 1 2028
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT06566092
Start Date
March 28 2024
End Date
July 1 2028
Last Update
June 29 2025
Active Locations (5)
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1
Children's Hospital of Colorado
Aurora, Colorado, United States, 80045
2
Johns Hopkins All Children's Hospital
St. Petersburg, Florida, United States, 33701
3
Rutgers Cancer Institute
New Brunswick, New Jersey, United States, 08901
4
Roswell Park Cancer Institute
Buffalo, New York, United States, 14203