Status:
RECRUITING
Bacterial Reduction After Supplementary Disinfection Procedures in Infected Root Canals
Lead Sponsor:
Abhishek Parolia
Conditions:
Dental Pulp Necroses
Eligibility:
All Genders
18-95 years
Phase:
NA
Brief Summary
The purpose of this study is to understand the effect that 3 different types of root canal procedures have on bacteria.
Detailed Description
Sample Size Calculation Sample size was calculated by STATISTICA v8.0 software (StatSoft, Tulsa, OK, USA), that demonstrated 23 teeth per group are needed to show a 5% difference in bacterial levels a...
Eligibility Criteria
Inclusion
- Diagnosis of pulp necrosis with apical periodontitis (AP) confirmed by pulp tests, clinical and radiographic evidence.
- Tooth with no response to cold and electric pulp testing (done at screening).
- Single canalled premolars with intact pulp chamber walls.
- Patient must be 18 years of age or older
Exclusion
- Teeth with vital pulp.
- Teeth with incomplete root formation (immature with apical periodontitis).
- Teeth with extensive crown destruction.
- Teeth with previous endodontic treatment or intervention (pulp debridement).
- Teeth with acute/ chronic apical abscess.
- Teeth with internal or external resorption.
- Teeth with non-odontogenic facial pain.
- Teeth with periodontal pockets deeper than 4 mm.
- Teeth with advanced untreated periodontal disease or recent periodontal surgery.
- Teeth with mobility score greater than 2.
- Teeth with a fracture or visible crack.
- Patients with diabetes or immune compromised conditions.
- Patients who received systemic antibiotics within the last 3 months.
- Patients taking corticosteroids.
- Patients who are pregnant.
Key Trial Info
Start Date :
August 20 2024
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
August 1 2026
Estimated Enrollment :
90 Patients enrolled
Trial Details
Trial ID
NCT06569329
Start Date
August 20 2024
End Date
August 1 2026
Last Update
September 17 2025
Active Locations (1)
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1
University of Iowa College of Dentistry and Dental Clinics
Iowa City, Iowa, United States, 52242