Status:
COMPLETED
Precision Application of Clostridium Butyricm of Clinical Research on Osteoarthritis
Lead Sponsor:
China Medical University Hospital
Collaborating Sponsors:
Grape King Bio Ltd.
Conditions:
Osteoarthritis
Knee
Eligibility:
All Genders
55-75 years
Phase:
NA
Brief Summary
Osteoarthritis (OA) is a common joint disease worldwide. The main symptom is that the mechanical wear of the cartilage in the joint and leads to the abnormal proliferation of the surrounding bone and ...
Eligibility Criteria
Inclusion
- \- A. Patients aged 55 to 75 years old with degenerative arthritis, diagnosed by a physician as suitable for participation in this experiment.
- B. Patients with early-stage degenerative arthritis symptoms, as interpreted by X-ray using the Kellgren Lawrence Grading Scale at grade 1 or 2, and determined by a physician to not require long-term treatment.
- C. Patients with a high pain index when the knee is extended 40-70 mm.
- D. Patients who feel knee pain, primarily those with a high Western Ontario and McMaster Universities Osteoarthritis (WOMAC) Index score (pain scale score \>2.0 or total WOMAC scale score \>12).
Exclusion
- \- A. Patients with a history of knee joint trauma or knee joint surgery (including arthroscopic surgery).
- B. Patients who have taken steroid medication for the treatment of degenerative arthritis.
- C. Patients with severe cardiovascular, cerebrovascular, rheumatic, or psychiatric diseases.
- D. Patients with joint pain caused by other factors.
- E. Patients with infectious diseases or acute infections (e.g., fever, localized inflammation, abscess).
- F. Patients with systemic or metabolic diseases, or progressive bone degeneration caused by medication.
- G. Cancer patients.
Key Trial Info
Start Date :
April 1 2023
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
February 29 2024
Estimated Enrollment :
83 Patients enrolled
Trial Details
Trial ID
NCT06570408
Start Date
April 1 2023
End Date
February 29 2024
Last Update
August 26 2024
Active Locations (1)
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1
China Medical University Hospital
Taichung, North District, Taiwan, 404327