Status:
RECRUITING
rTMS as an Intervention for Levodopa-induced Dyskinesia
Lead Sponsor:
Danish Research Centre for Magnetic Resonance
Conditions:
Dyskinesia, Drug-Induced
Parkinson Disease
Eligibility:
All Genders
18-80 years
Phase:
NA
Brief Summary
The proposed study investigates the use of repetitive transcranial magnetic stimulation (rTMS) as a treatment for levodopa-induced dyskinesia (LID) in Parkinson's Disease (PD). Specifically, the study...
Detailed Description
Long-term use of levodopa in Parkinson's Disease (PD) often leads to motor complications, such as Levodopa-Induced Dyskinesia, which significantly impacts patients' daily lives. Various brain regions ...
Eligibility Criteria
Inclusion
- Clinically established or probable PD
- Clinical Diagnostic Criteria for Parkinson's Disease
- Peak-of-dose levodopa-induced dyskinesia.
- Stable antiparkinsonian medicine for at least four weeks.
- Signed informed consent.
Exclusion
- Psychiatric disorders.
- Usage of antipsychotic medication, Donepezil, and GABAergic medications (such as pregabalin and gabapentin).
- Regular usage of benzodiazepines and opioids (more than once per week).
- History of neurological disease other than Parkinson's disease.
- History of epilepsy/conditions associated with increased risk to seizure-induction through TMS.
- Close relatives suffering from epilepsy/conditions associated with increased risk to seizure-induction through TMS.
- Contraindications for MRI scan
- Female participants of childbearing age must not be pregnant and that they must use contraception during the trial.
- Refuse to be informed about new health related information and accidental health related findings that might appear through participation in the study.
Key Trial Info
Start Date :
July 22 2024
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
May 1 2027
Estimated Enrollment :
68 Patients enrolled
Trial Details
Trial ID
NCT06570824
Start Date
July 22 2024
End Date
May 1 2027
Last Update
August 28 2024
Active Locations (1)
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1
DRCMR
Hvidovre, Denmark, 2650