Status:
ENROLLING_BY_INVITATION
Quantification of Myocardial Fibrosis in Aortis Stenosis
Lead Sponsor:
Norwegian University of Science and Technology
Collaborating Sponsors:
St. Olavs Hospital
Oslo University Hospital
Conditions:
Aortic Valve Stenosis
Myocardial Fibrosis
Eligibility:
All Genders
18-90 years
Brief Summary
This study is a long term follow-up of patients that were included as part of a previous study (NCT03422770), where patients with aortic stenosis and healthy controls went through echocardiography, ca...
Detailed Description
High frame rate ultrasound with quantification of myocardial mechanical wave velocities provides a new approach to evaluation of myocardial stiffness. Principle: An elastic medium (the left ventricle...
Eligibility Criteria
Inclusion
- Part of the initial cohort that were included in the baseline study
- Still able to undergo protocolled investigations
- Patients: Mild, moderate or severe AS
Exclusion
- Renal insufficiency
- Previously myocardial infarction (ECG, echocardiogram or hospital record)
- Severe valvular heart disease (except patients)
- Other cardiac disease known to cause myocardial fibrosis
- Severe hypertension
- Other medical conditions deterring protocolled investigation and follow-up
- Other medical conditions affecting 5-years prognosis (cancer, pulmonary disease)
- Severely reduced image-quality (echocardiography and MRI)
Key Trial Info
Start Date :
January 21 2025
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
April 15 2026
Estimated Enrollment :
70 Patients enrolled
Trial Details
Trial ID
NCT06571175
Start Date
January 21 2025
End Date
April 15 2026
Last Update
August 7 2025
Active Locations (1)
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1
St. Olavs Hosptial
Trondheim, Trøndelag, Norway, 7030