Status:
NOT_YET_RECRUITING
Study on the Relative Dose Intensity of PARP Inhibitors in Real-life on a Population of Patients Over 70 Years With Advanced Ovarian Cancer
Lead Sponsor:
Hospices Civils de Lyon
Conditions:
Ovarian Cancer
Eligibility:
FEMALE
70+ years
Brief Summary
Poly(ADP-ribose) polymerase (PARP) inhibitors are anti-cancer treatments that induce preferential tumor cell death. Their efficacy has been demonstrated in many tumor models, primarily in advanced ova...
Eligibility Criteria
Inclusion
- Age ≥ 70 years
- Histologically or cytologically confirmed diagnosis of advanced ovarian cancer (FIGO stage III or IV)
- PARP inhibitors -naive patient who need to initiate maintenance treatment with PARP inhibitors for the first time (according the the marketing authorization)
- Patient with a life expectancy of more then 3 months
- Informed patient which does not oppose to participate to the study
Exclusion
- Prior treatment with PARP inhibitors
- Patient incapable to take oral tablets/capsules
- Participation in a drug trial that does not authorize concurrent participation in another trials
- Person unable to attend scheduled examinations/appointments as part of routine care for geographical, social or psychological reasons
- Concomitant cancer or f cancer history (other than those included in the inclusion criteria) treated and considered cured for less than 2 years. However, patients with the following pathologies are eligible:
- Basal cell carcinoma or non-invasive cutaneous squamous cell carcinoma
- Stage 1B or less cervical carcinoma
- Non-invasive superficial bladder cancer
Key Trial Info
Start Date :
November 1 2024
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
May 1 2026
Estimated Enrollment :
50 Patients enrolled
Trial Details
Trial ID
NCT06572735
Start Date
November 1 2024
End Date
May 1 2026
Last Update
August 27 2024
Active Locations (9)
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1
Centre Hospitalier Universitaire d'Amiens Picardie Site Sud
Amiens, France, 80054
2
Centre de lutte contre le cancer Jean Perrin
Clermont-Ferrand, France, 63011
3
Groupe Hospitalier Public Sud de l'Oise
Creil, France, 60100
4
Centre Georges François Leclerc
Dijon, France, 21079