Status:
RECRUITING
Neurophysiology of Ankle Instability
Lead Sponsor:
University of Nebraska
Conditions:
Ankle Injuries
Eligibility:
All Genders
19-45 years
Phase:
NA
Brief Summary
Chronic ankle instability (CAI) is a common debilitating orthopedic condition that disrupts physical function and decreases quality of life. Not all CAI is the same. It can be mechanical ligamentous l...
Detailed Description
Chronic ankle instability (CAI) is a common debilitating orthopedic condition that disrupts physical function and decreases quality of life. CAI is heterogenous and can manifest as mechanical ligament...
Eligibility Criteria
Inclusion
- All participants must be physically active (participation in at least 90 total minutes of activity/week including running, walking, lifting weights, or playing a sport, etc.)
- Healthy controls:
- no history of lateral ankle sprain
- no complaints of their ankle giving way
- a Cumberland Ankle Instability Tool (CAIT) score greater than 28
- Coper participants (participants coping with ankle problems:
- a history of lateral ankle sprain, but no episodes of giving way in previous 12 months
- CAIT score greater than 28
- Chronic ankle instability (CAI):
- history of ankle sprain
- two or more episodes of ankle giving way in previous 12 months
- CAIT score less than 25
Exclusion
- History of lower extremity surgery or fracture
- Current signs or symptoms of a joint sprain in the lower extremity
- Pregnancy
- Diagnosis of a vestibular disorder
- Diagnosis of a nerve or connective tissue disorder
- Significant history of condition that impaired cognitive function such as concussion or learning disability
- Currently taking medications that may affect cognitive function such as narcotics, anti-depressants, anti-anxiety agents, or stimulants
Key Trial Info
Start Date :
September 23 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
September 1 2027
Estimated Enrollment :
42 Patients enrolled
Trial Details
Trial ID
NCT06576687
Start Date
September 23 2025
End Date
September 1 2027
Last Update
October 15 2025
Active Locations (1)
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1
University of Nebraska-Omaha, Biomechanics Research Building
Omaha, Nebraska, United States, 68182