Status:
ENROLLING_BY_INVITATION
Statistical Learning As a Novel Intervention for Cortical Blindness
Lead Sponsor:
University of Rochester
Conditions:
Stroke, Ischemic
Hemianopia, Homonymous
Eligibility:
All Genders
21-75 years
Phase:
NA
Brief Summary
This project aims to develop a novel visual training paradigm for use in visually-intact participants and those sufferings from stroke-induced visual impairments. Our task design is built upon theorie...
Eligibility Criteria
Inclusion
- Cortically Blind participants
- Inclusion criteria:
- Between 21 and 75 years of age
- Residents of the United States or Canada
- Have successfully completed previous enrollment in Dr. Huxlin study (IRB #5966 or #75)
- Exhibit unilateral stroke or stroke-like damage to primary visual cortex or its immediate afferent white matter sustained within the specified age range of 21 - 75 years (verified by MRI and/or CT scans)
- Reliable visual field defects in both eyes (homonymous defects) as measured by Humphrey visual fields. This deficit must be large enough to enclose a 5-deg diameter visual stimulus.
- Able to fixate on visual targets reliably for 1000ms within 1-deg of visual angle.
- Willing, able, and competent to provide their own informed consent
- Normal cognitive abilities and be able to understand written and oral instructions in English
- Exclusion criteria:
- Past or present ocular disease interfering with visual acuity
- Best corrected visual acuity (BCVA) worse than 20/40 in either eye
- Sustained documented or suspected damage to the dorsal Lateral Geniculate Nucleus
- Presence of diffuse whole brain degenerative processes
- History of traumatic brain injury
- Any other brain damage deemed by study staff to potentially interfere with training ability or outcome measures
- Documented history of drug/alcohol abuse
- Currently taking neuroactive medications which would impact training, as determined by PI
- Cognitive or seizure disorders
- One-sided attentional neglect
- Those who lack the competence or are otherwise unable to perform the visual training exercises as directed.
- Control participants
- Inclusion criteria:
- Between 21 and 75 years of age
- No history of neurological disorder.
- Competent and responsible, as determined by the screening interview
- Exclusion criteria:
- Any damage to the visual system
- Those who are suffering from an active disease process involving their nervous system.
- Presence of cognitive or seizure disorders
- Best corrected visual acuity worse than 20/40 in either eye
- Presence of visual field loss from ocular disease or disorder
Exclusion
Key Trial Info
Start Date :
November 6 2024
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
October 1 2027
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT06578117
Start Date
November 6 2024
End Date
October 1 2027
Last Update
December 16 2024
Active Locations (1)
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1
University of Rochester Medical Center
Rochester, New York, United States, 14642