Status:
RECRUITING
PRospective Observation on CErebral microvaScular Structure and Function
Lead Sponsor:
Beijing Tiantan Hospital
Collaborating Sponsors:
Beijing Daxing District People Hospital
Conditions:
Cerebral Microvascular Dysfunction
Cerebral Small Vessel Diseases
Eligibility:
All Genders
50-75 years
Brief Summary
This is a population-based prospective cohort study, aiming to assess the prevalence, distributional characteristics, and dynamic change of cerebral small vessel dysfunction in a Chinese community pop...
Detailed Description
Brain health is defined as normal brain structure, function and social adaptation and the absence of major brain diseases. Brain health is a lifespan-wide process that can be objectively measured and ...
Eligibility Criteria
Inclusion
- Community-dwelling adults aged 50-75 years;
- Registered Beijing household residents or residents who can be followed up stably in their own communities for a long period;
- Subjects with written informed consents.
Exclusion
- Residents with moderate to severe disabilities (MRS ≥3), mental illness, stroke, dementia, and other serious neurological disorders (e.g., encephalitis, Parkinson's disease, epilepsy, brain tumors, and rare genetic diseases of the nervous system);
- Life expectancy of ≤4 years due to serious diseases such as end-stage cancer;
- Contraindications to magnetic resonance imaging such as implanted devices (e.g., pacemakers, defibrillators, and others);
- Residents who are participating in other studies.
Key Trial Info
Start Date :
October 18 2024
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
October 1 2032
Estimated Enrollment :
3500 Patients enrolled
Trial Details
Trial ID
NCT06579677
Start Date
October 18 2024
End Date
October 1 2032
Last Update
January 6 2025
Active Locations (2)
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1
Beijing Tiantan Hospital
Beijing, Beijing Municipality, China, 100070
2
Beijing Daxing District People Hospital
Beijing, Beijing Municipality, China, 102600