Status:
RECRUITING
Efficacy and Mechanism of rTMS on the Symptoms of Pleasure Deficit in Adolescent Depression
Lead Sponsor:
Xijing Hospital
Conditions:
Depression
Eligibility:
All Genders
10-19 years
Phase:
NA
Brief Summary
(1) Primary objective: to collect data on the score of pleasure deficit scale before and after repetitive transcranial magnetic stimulation treatment in adolescent depressed patients, and to verify it...
Detailed Description
Depression is one of the most common mental disorders among adolescents and is characterized by persistent low mood. According to a global statistical report released by the World Health Organization,...
Eligibility Criteria
Inclusion
- Age 10-19 years old (both 10 and 19), gender is not limited;
- Meet the criteria for diagnosing MDD in the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5);
- First episode or relapse, monophasic or bipolar depressive disorder;
- No history of any form of antidepressant treatment (including medication, physical and psychotherapy) within 2 weeks prior to enrollment;
- Habitual right-handedness;
- Deficit of pleasure scale (DARS) \<22 points;
- Score \>17 on the 17-item version of the Hamilton Depression Scale (HAMD-17);
- After fully understanding the safety of rTMS, they were willing to actively cooperate with the treatment and signed an informed consent form.
Exclusion
- Complicated with psychotic symptoms;
- Comorbidity with major psychiatric disorders such as schizophrenia, delusional disorder, delirium, neurocognitive disorder, intellectual disability, and other mental disorders caused by other diseases;
- History of primary neurologic disease or brain injury;
- History of electroconvulsive therapy;
- Contraindications to rTMS treatment, including cardiac pacemakers, neurostimulators, artificial metal heart valves, intracranial aneurysm clips, cochlear implants, and other types of metal implants (with the exception of oral supports);(6)History of epilepsy.
Key Trial Info
Start Date :
September 5 2024
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 31 2025
Estimated Enrollment :
44 Patients enrolled
Trial Details
Trial ID
NCT06580249
Start Date
September 5 2024
End Date
December 31 2025
Last Update
September 23 2024
Active Locations (1)
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1
XijingH
Xi'an, Shaanxi, China, 710032