Status:
NOT_YET_RECRUITING
DNA Methylation Trajectories in Aging
Lead Sponsor:
University of Campania Luigi Vanvitelli
Conditions:
Heart Failure
Aging
Eligibility:
All Genders
18+ years
Brief Summary
The goal of this observational study is to profile changes in DNA methylation of circulating CD4+ T and CD8+ T cells from healthy young to aged with diagnosis of HFpEF, a particular phenotype of HF wh...
Eligibility Criteria
Inclusion
- Healthy subjects aged between 18 and 40 years
- Aged subjects (≥65) without signs and symptoms of heart failure
- Aged subjects (≥65) with diagnosis of heart failure with preserved ejection fraction (EF major than 50%)
Exclusion
- Heart failure with reduced ejection fraction (EF minor than 40%)
- Heart failure with mildly reduced EF (HFmrEF) (EF 41-49%)
- History or diagnosis of cancer and inflammatory diseases
Key Trial Info
Start Date :
November 1 2024
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
November 1 2025
Estimated Enrollment :
150 Patients enrolled
Trial Details
Trial ID
NCT06582992
Start Date
November 1 2024
End Date
November 1 2025
Last Update
September 3 2024
Active Locations (1)
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1
University of Campania Luigi Vanvitelli
Naples, No States Available, Italy, 80138