Status:
RECRUITING
Black Rice Consumption on Cognitive Function, Inflammation and Microvascular Function in Older Adults
Lead Sponsor:
University of Reading
Conditions:
Older Adults
Eligibility:
All Genders
50-80 years
Phase:
NA
Brief Summary
Cognitive (brain) function, especially memory, gradually declines during ageing, which may in part be caused by an increase in systemic inflammation as well as a reduction in vascular functions and ce...
Detailed Description
This study is a randomised controlled crossover design with a week wash-out period for investigating the acute (2 hrs), short-term (7 days), and acute on short-term (7 days, 2 hrs) effects of black ri...
Eligibility Criteria
Inclusion
- Aged 50-80 years
- General healthy status
- Body Mass Index (BMI)18.5-35 kg/m2
Exclusion
- Taking anti-inflammatory drugs (e.g., aspirin, warfarin, ibuprofen)
- Having sign of infections or acute inflammation (e.g., fever, chills, sore throat, nasal congestion, moderate-severe pain, swelling-redness)
- Received antibiotics within the past 3 months
- Taking dietary supplements (e.g., vitamins, minerals) at high doses (e.g., more than 200% of the UK's reference nutrient intakes)
- Taking hormone replacement therapy, if you are menopausal
- Had major surgery (head, heart, chest, abdomen) within the past 6 months.
- Having plan to start to a restricted diet/ changing dietary pattern or lose weight.
- Diagnosed with neurodegenerative diseases (e.g., Dementia, Alzheimer's, Parkinson's, current stroke)
- Diagnosed with psychotic disorders (e.g., schizophrenia, bipolar depression, eating disorder)
- Diagnosed with cardiovascular disease, diabetes, hyperlipidemia, hypertension (blood pressure\>140/90 mmHg), active cancer, liver, or kidney diseases.
- Taking medication to lower blood fats (e.g., statins, fibrates) or to stabilise blood glucose (e.g., acarbose, metformin or sulfonylureas) or lower blood pressure.
- Unable to complete the cognitive function tasks for any reason (i.e., visual impairments, hearing loss)
- If you have a peacemaker
- If you have bleeding disorders or blood related diseases (anaemia, thalassemia, thrombosis, embolism)
- Heavy smoker
- Heavy alcohol drinking (\> 14 units/week) or a history of alcohol/substance abuse
- Allergies, hypersensitivity, or food intolerances (rice, eggs, soy sauce, vegetable oil)
Key Trial Info
Start Date :
December 5 2023
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 31 2024
Estimated Enrollment :
24 Patients enrolled
Trial Details
Trial ID
NCT06583785
Start Date
December 5 2023
End Date
December 31 2024
Last Update
September 4 2024
Active Locations (2)
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1
Hugh Sinclair Unit of Human Nutrition
Reading, UK, United Kingdom, RG2 6AP
2
Hugh Sinclair Unit of Human Nutrition, Department of Food and Nutritional Sciences, University of Reading
Reading, United Kingdom, RG2 6AP