Status:
RECRUITING
Effect of Sodium Glucose Co-tansporter 2 Inhibitors (SGLT2I) on Inflammatory and Oxidative Stress Markers Level in Heart Failure Patients
Lead Sponsor:
Kafrelsheikh University
Conditions:
Heart Failure
Eligibility:
All Genders
18-80 years
Brief Summary
The aim of this study is to explore the effect of SGLT2i on the levels of cardiac biomarkers, inflammatory and stress markers in Egyptian heart failure patients to provide a better understanding of me...
Eligibility Criteria
Inclusion
- Patients aged more than 18 years old.
- Patients are with cardiac function was graded as II-IV by the New York Heart Association (NYHA)
- Patients are on standard therapy for management of HF (according to AHA/ACC/HFSA Guideline for the Management of Heart Failure2022)21 such as:
- ACEi (angiotensin converting enzyme inhibitor)
- ARB (angiotensin receptor blocker)
- ARNI in place of ACEi OR ARB
- Beta blocker
- (MRA) Mineralocorticoid receptor antagonists
- Diuretics as needed.
- All patients signed the informed consent.
Exclusion
- Patients suffering from conditions like acute CVS illness and severe sepsis that raise inflammatory markers and may lead to cardiac dysfunction as opposed to heart failure.
- Patients with various cardiac conditions, such as severe congenital heart disease, myocarditis, and valvular heart disease.
- Female patients during pregnancy or lactation
- Individuals suffering from a malignant tumor, hyperfunctioning thyroid, multiple organ failure, or significantly reduced kidney function (eGFR \<20 mL/min/1.73 m²).
- Individuals suffering from verbal communication disorders or psychic cognitive impairment.
Key Trial Info
Start Date :
February 15 2024
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
June 30 2025
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT06585761
Start Date
February 15 2024
End Date
June 30 2025
Last Update
September 5 2024
Active Locations (1)
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1
Kafrelsheikh University Hospital
Kafr ash Shaykh, Egypt, 33516