Status:
COMPLETED
Accelerated Image-Guided Robotically Delivered Transcranial Magnetic Stimulation for Combat PTSD
Lead Sponsor:
The University of Texas Health Science Center at San Antonio
Collaborating Sponsors:
Trauma Research and Combat Casualty Care Collaborative
Conditions:
Stress Disorders, Post-Traumatic
Eligibility:
All Genders
18-70 years
Phase:
NA
Brief Summary
Posttraumatic stress disorder (PTSD) among military service members and veterans is as high as 32% and is the third most service-connected disability, resulting in over $1.5 billion in direct costs ov...
Detailed Description
We propose an open-label, 2-week trial of IR-TMS targeting the right, anterior dorsolateral prefrontal cortex (R-antDLPFC) in 30 PTSD participants. We will recruit Active-Duty Service Members and Vete...
Eligibility Criteria
Inclusion
- between the ages of 18 and 70 years
- meet diagnostic criteria for PTSD on the CAPS-5
- able to attend all clinic appointments
- fluent in English
Exclusion
- a documented diagnostic history of bipolar disorder, schizophrenia or schizoaffective disorder or a psychiatric hospitalization in the last 12 months
- significant cognitive impairment determined by inability to comprehend screening assessment
- psychiatric problems and/or high suicide risk warranting immediate intervention, as assessed with the PHQ-9 (Item #9)
- currently meeting a psychiatric diagnosis of alcohol and/or substance abuse that would prevent the participant from engaging in therapy
- any history or signs of serious medical or neurological illness including seizure disorders
- history of traumatic brain injury (TBI) with loss of consciousness for 20 minutes or more
- females will be excluded if they are pregnant
- any history or signs of metal objects deemed unsafe for MRI or that may adversely affect image quality of the brain region (e.g. surgical clips, cardiac pacemakers, metal implants, etc.) in the body at the time of screening.
Key Trial Info
Start Date :
January 2 2025
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 31 2025
Estimated Enrollment :
7 Patients enrolled
Trial Details
Trial ID
NCT06587659
Start Date
January 2 2025
End Date
July 31 2025
Last Update
October 15 2025
Active Locations (1)
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1
Research Imaging Institute
San Antoio, Texas, United States, 78229