Status:
NOT_YET_RECRUITING
Small Diameter TIPS in Patients with Severe Liver Atrophy and Variceal Bleeding
Lead Sponsor:
Huang Mingsheng
Conditions:
Portal Hypertension Related to Cirrhosis
Eligibility:
All Genders
18-70 years
Phase:
NA
Brief Summary
Portal hypertension is the most common complication in patients with end-stage liver cirrhosis. Portal hypertension-related complications, such as variceal bleeding, often lead to a poor prognosis. Tr...
Eligibility Criteria
Inclusion
- Diagnosed as cirrhosis
- Previous or present endoscopic diagnosis of esophageal and gastric varices bleeding.
- Child -Pugh score C (≤13) or MELD≤18.
- Enhanced image measurement of liver volume ≤1000cm3.
- Have indications for TIPS treatment.
- Researchers believe that patients have the ability to comply with the research plan.
- Sign the informed consent form
Exclusion
- Malignant tumor (including hepatocellular carcinoma) or other diseases that will shorten the life span of patients.
- Cavernous portal vein
- Non-cirrhotic portal hypertension (Budd-Chiari syndrome, extrahepatic portal vein obstruction, idiopathic portal hypertension, etc.)
- Spontaneous dominant hepatic encephalopathy 5 congestive heart failure or severe valvular heart failure
- 6\. Uncontrollable systemic infection or inflammation 7. Severe pulmonary hypertension 8. Severe renal insufficiency (except hepatogenic renal insufficiency) 9. Rapidly progressing liver failure 10. Contrast agent allergy 11. History of liver transplantation or allogeneic organ transplantation 12. Have a history of TIPS or shunt operation. 13. Pregnancy or lactation 14. Poor compliance 15. Participate in another clinical study.
Key Trial Info
Start Date :
September 15 2024
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
September 15 2028
Estimated Enrollment :
120 Patients enrolled
Trial Details
Trial ID
NCT06589531
Start Date
September 15 2024
End Date
September 15 2028
Last Update
September 19 2024
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