Status:
NOT_YET_RECRUITING
Autonomic Modulation in Patients Undergoing Assisted Mechanical Ventilation: Comparison Between PAV+ and PSV
Lead Sponsor:
University of Roma La Sapienza
Conditions:
Mechanical Ventilation Weaning
Eligibility:
All Genders
18+ years
Brief Summary
The aim of the study is to investigate autonomic modulation in terms of heart rate variability (i.e., HRV) in patients undergoing assisted mechanical ventilation in PSV mode, compared to patients assi...
Eligibility Criteria
Inclusion
- Patients admitted to the ICU, ≥18 years old, undergoing invasive controlled mechanical ventilation for at least 72 hours, eligible for assisted support but not yet ready for extubation or spontaneous breathing.
Exclusion
- Successful completion of a spontaneous breathing trial (SBT) and spontaneous breathing within 24 hours of enrollment
- Acute ischemic heart disease, cardiac rhythm abnormalities, and/or patients with pacemakers and/or treated with anti-arrhythmic drugs
- Hemodynamic instability
- Chest drainage
- Severe anemia (Hb \<7g/dL)
- Pregnancy
- Severe head trauma, dementia
- High spinal cord injury
- Neuromuscular disorders
- Lack of consent
Key Trial Info
Start Date :
September 15 2024
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 15 2025
Estimated Enrollment :
48 Patients enrolled
Trial Details
Trial ID
NCT06590311
Start Date
September 15 2024
End Date
December 15 2025
Last Update
September 19 2024
Active Locations (1)
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1
AOU Policlinico Umberto I
Rome, Italy