Status:
RECRUITING
The STatus Epilepticus Prognosis Study
Lead Sponsor:
London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Conditions:
Status Epilepticus
Eligibility:
All Genders
18-80 years
Brief Summary
The goal of this study is to improve the prognosis of patients who present with Status Epilepticus (SE). In the first part of this study, the investigators aim to find better markers of good and poor ...
Detailed Description
Treatment guidelines and predictive markers of neurologic recovery in status epilepticus (SE) and refractory SE are inadequate, which makes prognostication of neurological outcome a substantial clinic...
Eligibility Criteria
Inclusion
- 18 to 80 years of age
- SE requiring admission to critical care
- Developed SE while in ICU
- No history of a neurologic condition, other than epilepsy, that would impact cognition (Dementia, Parkinson's disease, Alzheimer's disease)
- Absence of devastating neurologic injury (cardiac arrest, stroke, traumatic brain injury)
- In addition, for non-SE epilepsy controls for Creyos task:
- People with epilepsy
- No history of status epilepticus
- Patient has not stereotaxic EEG monitoring
- English speaking
- No history of a neurologic condition, other than epilepsy, that would impact cognition (Dementia, Parkinson's disease, Alzheimer's disease)
- In addition, for follow up MRI purposes only:
- Diagnosed with refractory status epilepticus while in ICU
- No MRI contraindications (metal in body, pacemakers, etc.)
- Inclusion Criteria Healthy Control Population for MRI imaging:
- No history of a neurologic condition that would impact cognition (Dementia, Parkinson's disease, Alzheimer's disease)
- No MRI contraindications (metal in body, pacemakers, etc.)
Exclusion
- patients not meeting inclusion criteria
- acute brain injury or brain tumour as immediate cause of status epilepticus
Key Trial Info
Start Date :
November 27 2022
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 31 2026
Estimated Enrollment :
50 Patients enrolled
Trial Details
Trial ID
NCT06590883
Start Date
November 27 2022
End Date
December 31 2026
Last Update
September 19 2024
Active Locations (1)
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1
Lawson Health Research Institute
London, Ontario, Canada, N6C 2R5