Status:
TERMINATED
A Double-blind, Placebo-controlled, Parallel-group Study to Evaluate the Safety and Efficacy of Briquilimab in Participants With Allergic Asthma
Lead Sponsor:
Jasper Therapeutics, Inc.
Conditions:
Allergic Asthma
Eligibility:
All Genders
18-65 years
Phase:
PHASE1
Brief Summary
Study JSP-CP-012 is designed as a proof of concept, parallel-group, single dose, double blind, placebo-controlled study using an allergen challenge model. A single dose proof of concept approach at a ...
Eligibility Criteria
Inclusion
- Men and women 18 to 65 years of age; stable, allergic asthma; history of episodic wheeze and shortness of breath; forced expiratory volume in 1 second (FEV1) at baseline at least 70% of the predicted value; able to comprehend and follow all required study procedures; willing and able to sign an informed consent form; positive methacholine challenge at baseline (concentration of methacholine causing 20% decrease in FEV1 \[PC20\] PC20 ≤ 16 mg/mL or PD20 equivalent to ≤400µg); and positive skin-prick test and positive allergen-induced early and late airway bronchoconstriction to common aeroallergens.
Exclusion
- Worsening of asthma or respiratory infection in the preceding 6 weeks; lung disease other than allergic asthma; prior treatment with a c-Kit inhibiting therapy; anaphylaxis to any parenterally administered biologics; use of asthma medications (note: intermittent doses of short-acting β2-agonist are allowed once weekly for relief of symptoms but prophylactic use for exercise is allowed as-needed); pregnant or lactating women; and women actively seeking pregnancy or who are not using adequate contraception.
Key Trial Info
Start Date :
November 26 2024
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
August 11 2025
Estimated Enrollment :
17 Patients enrolled
Trial Details
Trial ID
NCT06592768
Start Date
November 26 2024
End Date
August 11 2025
Last Update
September 16 2025
Active Locations (6)
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1
University of Calgary
Calgary, Alberta, Canada, T2N 1N4
2
University of Alberta
Edmonton, Alberta, Canada, T6G 2R3
3
University of British Columbia
Vancouver, British Columbia, Canada, V6T 1Z4
4
McMaster University
Hamilton, Ontario, Canada, L8N 3Z5