Status:
RECRUITING
Quzhou Population Cohort Research Project (Aging Related Research: Intervention of Nicotinamide Mononucleotide in Middle-aged and Elderly People)
Lead Sponsor:
People's Hospital of Quzhou
Collaborating Sponsors:
Beijing Institute of Genomics, Chinese Academy of Sciences
Institute of Zoology, Chinese Academy of Sciences
Conditions:
Aging
NMN
Eligibility:
All Genders
40-70 years
Phase:
NA
Brief Summary
This study is a single center, randomized, double-blind, placebo-controlled clinical trial of drug intervention on aging. The purpose is to explore the effectiveness of NMN on the premise of ensuring ...
Eligibility Criteria
Inclusion
- Inclusion criteria：
- Local residents of Quzhou or living in Quzhou for over ten years.
- age 40-50 and 60-70 years old, no major bad habits.
- Gender unlimited.
- in good health and has not undergone major surgery within half a year.
- Be able to communicate well with researchers and cooperate with the work during the study.
- Written informed consent can be signed voluntarily.
- Exclusion criteria：
- Alcoholism, heavy smoking (more than 5 packs/day, 20 cigarettes per pack), drug abuse or substance abuse.
- Participants are conducting other clinical trials or using any research drugs or equipment for treatment within 30 days before enrollment (including but not limited to aspirin, metformin, resveratrol, vitamin C, etc.).
- Obesity (bmi more than 30).
- Pregnant/lactating women.
- Disease history:
- A) under 60 years old:
- any cancer (erythrocytosis, except basal cell or squamous cell skin cancer).
- coronary artery disease/myocardial infarction/clinically significant congestive heart failure.
- stroke/transient ischemic attack.
- deep vein thrombosis/pulmonary embolism.
- serum creatinine \> 1.5 mg/dl (male).
- poor control of hypertension (although treated, there is still significant hypertension (systolic blood pressure \> 160 mmHg, or diastolic blood pressure \>100 mmHg)).
- history of active liver disease or metabolic acidosis.
- chronic kidney disease/hemodialysis treatment, history of severe kidney damage and/or EGFR ≤ 45ml/min/1.73m2.
- severe autoimmunity/inflammation, such as rheumatoid arthritis, lupus, Crohn\'s disease, etc.
- nervous system diseases such as dementia, such as Alzheimer/Parkinson\'s disease.
- diabetes mellitus (hemoglobin \> 6.5% or fasting blood glucose \> 126 mg/dL or taking diabetes drugs or insulin treatment).
- recent (within 3 months) cardiovascular events (myocardial infarction, coronary intervention, coronary artery bypass grafting).
- infectious diseases such as HIV, hepatitis, tuberculosis, etc.
- hand or lower limb disability affects normal function and life.
- B) older than 60 years:
- any cancer (erythrocytosis, except basal cell or squamous cell skin cancer).
- history of active liver disease or metabolic acidosis.
- chronic kidney disease/hemodialysis treatment, history of severe kidney damage and/or EGFR ≤ 45ml/min/1.73m2.
- severe autoimmunity/inflammation, such as lupus, Crohn\'s disease, etc.
- nervous system diseases such as dementia, such as Alzheimer/Parkinson\'s disease.
- recent (within 3 months) cardiovascular events (myocardial infarction, coronary intervention, coronary artery bypass grafting).
- infectious diseases such as HIV, hepatitis, tuberculosis, etc.
- hand or lower limb disability affects normal function and life.
- Currently taking the following drugs regularly:
- A) chemotherapy drugs (such as tamoxifen, adriamycin, mitoxantrone, bleomycin). B) antiplatelet drugs (e.g., clopidogrel/Plavix, dipyridamole/anglionide, ticlopidine/ticlopidine, except aspirin).
- C) cholinesterase inhibitors for Alzheimer\'s disease (donepezil/alicept).
- The researchers believe that the physical factors of the participants may have an adverse impact on the research process or results.
Exclusion
Key Trial Info
Start Date :
August 23 2023
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 31 2026
Estimated Enrollment :
240 Patients enrolled
Trial Details
Trial ID
NCT06592859
Start Date
August 23 2023
End Date
December 31 2026
Last Update
June 29 2025
Active Locations (1)
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1
People's Hospital of Quzhou
Quzhou, Zhejiang, China, 324000