Status:
RECRUITING
Mapping Corticoreticulospinal Motor Control in Chronic Hemiparetic Stroke
Lead Sponsor:
Northwestern University
Collaborating Sponsors:
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Conditions:
Stroke
Hemiparesis
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
This study uses functional magnetic resonance imaging to map neural activity throughout the central nervous system during a shoulder abduction task to characterize what motor pathways are being used p...
Detailed Description
Nearly 85% of stroke survivors experience significant unilateral impairment in upper extremity motor control, typically caused by damage to the corticospinal (CST) and corticoreticular (CRT) tracts (i...
Eligibility Criteria
Inclusion
- Adults aged at least 18y
- Able to perform shoulder abduction task (confirmed during screening and initial examination)
- Safe to undergo MRI
- Able to follow visual instructions using MRI-compatible vision correction goggles
- No brainstem or cerebellar lesions
- No severe concurrent medical problems
- Cognitive/attentional capacity to focus on a task
- Able to communicate in English or Spanish
- Additional inclusion criteria for stroke participants:
- Have sustained only one unilateral subcortical, ischemic lesion in the territory supplied by the Middle Cerebral Artery (confirmed by clinical or radiological reports) at least one year prior to participation in this project
- Paresis confined to one side, with moderate-to-severe motor impairment of the upper limb (Upper Extremity Fugl-Meyer score between 10 and 45).
Exclusion
- MRI contraindications
- Severe claustrophobia
- Pregnant women
- Prisoners
- Vulnerable populations
- Diagnosis/history of:
- multiple sclerosis
- brain tumor
- brain radiation
- traumatic brain injury
- dementia
- Parkinson's disease
- Concurrent enrollment in an intervention study
- Concurrent use of medications known to suppress central nervous system activity
Key Trial Info
Start Date :
May 20 2023
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
August 31 2026
Estimated Enrollment :
32 Patients enrolled
Trial Details
Trial ID
NCT06598150
Start Date
May 20 2023
End Date
August 31 2026
Last Update
October 1 2025
Active Locations (1)
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1
Northwestern University
Chicago, Illinois, United States, 60611