Status:
RECRUITING
Chlorhexidine Lavage for Recurrent Urinary Tract Infection
Lead Sponsor:
Oregon Health and Science University
Conditions:
Urinary Tract Infections
Recurrent Urinary Tract Infection
Eligibility:
FEMALE
55-89 years
Phase:
PHASE4
Brief Summary
A two-arm randomized control trial evaluating rates of urinary tract infection in post-menopausal women on vaginal estrogen with recurrent urinary tract infections.
Detailed Description
There is a critical need for low-cost, non-antibiotic interventions that are feasible for patients to utilize for risk reduction and prevention of recurrent urinary tract infections (UTIs). The curren...
Eligibility Criteria
Inclusion
- Post-menopausal female between age 55 and 89
- No post-menopausal bleeding
- Diagnosis of recurrent urinary tract infection (UTI) in the electronic health record or as two culture proven UTIs in 6 months or three culture proven UTIs in 12 months
- At least one UTI in the 6 months prior to entering the study
- Asymptomatic for UTI symptoms at the time of enrollment.
- On vaginal estrogen therapy for at least 6 weeks prior to enrollment
- Ready access to email and internet
Exclusion
- Recent prophylactic antibiotic use (washout period of 4 weeks)
- Neurogenic bladder
- Diagnosis of urinary retention
- Uncorrected Stage III-IV prolapse
- Indwelling catheter or need for intermittent self-catheterization
- History of complicated UTIs
- History of interstitial cystitis or bladder pain syndrome
- History of fecal incontinence/accidental bowel leakage
- Greater than 14 bowel movements per week
- Non-English speaking
- Allergy to chlorhexidine gluconate
- Inability to utilize vaginal estrogen therapy
- Recent urogynecological or urologic surgery (\<12 weeks)
Key Trial Info
Start Date :
December 23 2024
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
June 1 2026
Estimated Enrollment :
136 Patients enrolled
Trial Details
Trial ID
NCT06598514
Start Date
December 23 2024
End Date
June 1 2026
Last Update
March 24 2025
Active Locations (1)
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1
Oregon Health & Science University
Portland, Oregon, United States, 97239