Status:
RECRUITING
Neuromodulation-assisted Ego-disengagement: The NEURO-EGO Study Stage 1
Lead Sponsor:
University of Wisconsin, Madison
Collaborating Sponsors:
Tiny Blue Dot Foundation
Conditions:
Healthy
Eligibility:
All Genders
18-80 years
Phase:
NA
Brief Summary
The goal of this clinical trial is to learn whether brain stimulation technology can help people reach a meditative state quickly and easily without years of meditation training. The researchers want ...
Detailed Description
This study is being done to evaluate the relative effectiveness of distinct types of non-invasive brain stimulation - NIBS (TES-TI and TES) on subjective ego disengagement and cortical activity in exp...
Eligibility Criteria
Inclusion
- Adults, ages 18 to 80 of any identified gender
- Medically healthy
- English-speaking (able to provide consent and complete questionnaires)
- Healthy adults with a consistent meditation practice
- Citizen or legal resident
Exclusion
- Any current or past history of neurological disorders or acquired neurological disease (e.g. stroke, traumatic brain injury), including intracranial lesions
- Any current or past history of bipolar disorder and/or hypomania
- Any current or past history of psychosis
- History of head trauma resulting in prolonged loss of consciousness; or a history of greater than 3 grade I concussions
- Current history of poorly controlled headaches including intractable or poorly controlled migraines
- Any systemic illness or unstable medical condition that may cause a medical emergency in case of a provoked seizure (cardiac malformation, cardiac dysrhythmia, asthma, etc.)
- History of fainting spells of unknown or undetermined etiology that might constitute seizures
- History of seizures, diagnosis of epilepsy, history of abnormal (epileptiform) EEG, or family history of treatment resistant epilepsy with the exception of a single seizure of benign etiology (e.g. febrile seizures) in the judgment of a board-certified neurologist
- Possible pregnancy. All female participants of child-bearing age are required to have a pregnancy test
- Any metal in the brain, skull or head
- Any contraindications to MRI
- Any medical devices or implants (i.e. cardiac pacemaker, medication infusion pump, cochlear implant, vagal nerve stimulator, dental implants (this includes a permanent retainer)) unless otherwise approved by the responsible MD
- Substance abuse or dependence within the past six months
- Any medication that may alter seizure threshold i.e., ADHD stimulants (Adderall, amphetamine); Tricyclic/atypical antidepressants (Amitriptyline, Dioxepine, Imipramine Maprotiline, Nortriptyline, Bupropion); Antipsychotics (Chlorpromazine, Clozapine), Bronchodilators (theophylline, aminophylline); Antibiotics (fluoroquinolones, imipenem, penicillin, cephalosporins, metronidazole, isoniazid); Antiviral (Valacyclovir, Ritonavir); OTC (Diphenhydramine)
- Claustrophobia (a fear of small or closed places)
- Back problems that would prevent lying flat for up to two hours
- Motion sickness
- Any hair braid, dreadlocks, hair pieces, or extensions which cannot be taken out or adjusted to permit comfortable and comprehensive participation before the MRI scans and/or stimulation sessions
- Any head coverings or headdress that participant feels uncomfortable removing for the purposes of the MRI scans and/or stimulation session
Key Trial Info
Start Date :
January 8 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
October 1 2027
Estimated Enrollment :
12 Patients enrolled
Trial Details
Trial ID
NCT06601686
Start Date
January 8 2025
End Date
October 1 2027
Last Update
November 12 2025
Active Locations (1)
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1
University of Wisconsin
Madison, Wisconsin, United States, 53719