Status:
RECRUITING
Prevalence of Antibodies and Cytokines in Participants With Chronic Granulomatous Disease
Lead Sponsor:
Ensoma
Conditions:
Chronic Granulomatous Disease (CGD)
Eligibility:
All Genders
Brief Summary
This research study is designed to assess the prevalence of specific antibodies and inflammatory cytokines in adult and pediatric participants with CGD.
Detailed Description
In this observational study, blood samples will be collected from adult and pediatric patients with CGD. The level of circulating adenovirus antibodies and inflammatory cytokines will be measured to c...
Eligibility Criteria
Inclusion
- The participant must have been diagnosed with CGD based on the referring physician's confirmation that NADPH oxidase activity is ≤5% (i.e., the percentage of dihydrorhodamine-positive \[DHR+\] cells is ≤5% by flow cytometry) OR based on confirmed pathogenic mutation in a CGD associated gene (CYBB, CYBA, NCF1, NCF2, NCF4, or CYBC1).
- The participant or the participant's legally authorized guardian or representative (if applicable) must be capable of giving signed informed consent.
- The participant (with assistance from the participant's legally authorized guardian/representative or primary caregiver, if applicable) must be capable of complying with the requirements and restrictions listed in the protocol and informed consent form (ICF).
Exclusion
- The participant has undergone an allogeneic bone marrow transplant or investigational gene therapy.
- The participant is unable to comply with the sample collection procedure based on investigator judgment.
Key Trial Info
Start Date :
November 18 2024
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 1 2025
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT06605378
Start Date
November 18 2024
End Date
December 1 2025
Last Update
October 21 2025
Active Locations (52)
Enter a location and click search to find clinical trials sorted by distance.
1
Home-based telemedicine
Montgomery, Alabama, United States, 36104
2
Home-based telemedicine
Phoenix, Arizona, United States, 85001
3
Home-based telemedicine
Little Rock, Arkansas, United States, 72201
4
Home-based telemedicine
Sacramento, California, United States, 95814