Status:
NOT_YET_RECRUITING
Cerebral Hypoperfusion at Transcranial Color-Coded Doppler.
Lead Sponsor:
Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Conditions:
Cerebral Injury
Eligibility:
All Genders
18+ years
Brief Summary
Background. Cerebral ischemia is a major secondary factor contributing to worsening outcomes in patients with acute brain injuries. Transcranial Color-Coded Doppler (TCCD) is a reliable method for eva...
Eligibility Criteria
Inclusion
- Age over 18 years
- Patients with intraparenchymal cerebral hemorrhage, subarachnoid hemorrhage, head trauma, or hydrocephalus
- Glasgow Coma Scale belowe 9
- Need for invasive mechanical ventilation
- Arterial catheter for invasive blood pressure monitoring and blood sampling
- Presence of Doppler parameters of cerebral hypoperfusion (concurrent presence of two or more of the following conditions: PI \> 1.4, diastolic velocity \< 20 cm/s, and mean velocity \< 30 cm/s detected in at least one middle cerebral artery)
Exclusion
- Absence of transtemporal windows bilaterally on TCCD
- Documented severe aortic valve insufficiency
- Heart rate less than 40 bpm
- Patients with suspected vasospasm on TCCD
Key Trial Info
Start Date :
October 1 2024
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
March 31 2026
Estimated Enrollment :
100 Patients enrolled
Trial Details
Trial ID
NCT06607211
Start Date
October 1 2024
End Date
March 31 2026
Last Update
September 23 2024
Active Locations (1)
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1
Fondazione Policlinico Universitario A. Gemelli IRCCS, UOSD TERAPIA INTENSIVA NEUROCHIRURGICA
Rome, Lazio, Italy, 00168