Status:
NOT_YET_RECRUITING
The Clinical Efficacy of CT-Guided All-in-One Adaptive Emergency Radiotherapy for Spinal Cord Compression Caused by Spinal Metastases
Lead Sponsor:
Peking University Third Hospital
Conditions:
Malignant Spinal Cord Compression
Eligibility:
All Genders
18-80 years
Brief Summary
The aim of this study is to implement a new protocol for concurrent and sequential dose-escalation radiotherapy based on CT-guided all-in-one adaptive emergency radiotherapy for spinal cord compressio...
Detailed Description
Spinal Cord Compression Syndrome (SCCS) is a clinical syndrome caused by space-occupying lesions within the spine or spinal canal. These lesions exert pressure on the spinal cord, spinal nerve roots, ...
Eligibility Criteria
Inclusion
- (1)Diagnosed with MSCC due to spinal metastases confirmed by imaging (MRI or CT).
- (2)Acute or subacute onset of MSCC. (3)Modified Tokuhashi score for spinal metastases ≥ 9, indicating an expected survival time \> 6 months.
- (4)Spinal instability neoplastic score (SINS) ≤ 7, indicating spinal stability. (5)General performance status (Karnofsky score) ≥ 60. (6)No prior radiotherapy or surgical treatment for the spinal metastases before enrollment.
- (7)Patient refuses or is intolerant to surgery. (8)No other severe comorbidities, such as uncontrolled infections or serious cardiopulmonary diseases, that may affect radiotherapy outcomes or increase treatment risks.
- (9)No other active malignancies (except for the primary tumor and spinal metastases) to ensure the study's focus.
- (10)Age 18 years or older. (11)Informed consent obtained from the patient. (12) Accept CT guided spinal cord compression all in one adaptive emergency radiotherapy for spinal metastases.
Exclusion
- \- (1)History of radiotherapy or surgery in the affected spinal region leading to MSCC.
- (2)Intolerance to radiotherapy. (3)Severe psychiatric or neurological disorders. (4)Pregnant or breastfeeding women. (5)Clear indications that the affected spinal cord region requires decompression surgery first.
Key Trial Info
Start Date :
March 1 2025
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
August 1 2026
Estimated Enrollment :
50 Patients enrolled
Trial Details
Trial ID
NCT06608108
Start Date
March 1 2025
End Date
August 1 2026
Last Update
January 24 2025
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