Status:
RECRUITING
Intermittent Theta-burst Stimulation for Mild Cognitive Impairment
Lead Sponsor:
The Hong Kong Polytechnic University
Conditions:
Mild Cognitive Impairment (MCI)
Eligibility:
All Genders
65+ years
Phase:
NA
Brief Summary
The objectives of this study are to: 1. Evaluating the Impact of iTBS on Cognitive and Physical Functions: The investigators will investigate the efficacy of intermittent theta burst stimulation (iTB...
Detailed Description
Mild cognitive impairment (MCI) is a syndrome characterized by cognitive decline that is greater than expected with normal aging; however, it is not severe enough to meet dementia criteria. Accordingl...
Eligibility Criteria
Inclusion
- Aged≥65 years;
- Patient-reported subjective cognitive decline and the total score of the Hong Kong version of Montreal Cognitive Assessment (HK-MoCA) was between 19 and 25;
- Intact daily functioning in ADL scales and being independent in daily living, and ability to walk at least for 1 minute independently without an assistive device;
- No serious visual or hearing impairment and can complete relevant assessment and testing;
- Signed informed consent of patients and their families for iTBS treatment.
Exclusion
- Identified with contraindications in the rTMS screening questionnaire;
- Cognitive dysfunction due to craniocerebral trauma or neurological diseases;
- Presence of severe physical illnesses such as speech disorders or unstable cardiac arrhythmias;
- Currently in a critical condition such as fever, infection, or organ failure;
- Significant damage to the left frontal lobe cortex;
- Currently taking antidepressants or psychostimulants;
- Unstable vital signs or organ failure;
- Neuropsychiatric comorbidity or affective disorder that could affect the test results;
- Patients with dementia.
Key Trial Info
Start Date :
November 1 2024
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
October 31 2027
Estimated Enrollment :
66 Patients enrolled
Trial Details
Trial ID
NCT06608316
Start Date
November 1 2024
End Date
October 31 2027
Last Update
March 13 2025
Active Locations (2)
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1
The Hong Kong Polytechnic University
Hong Kong, Hong Kong, Hong Kong, 000000
2
The Hong Kong Polytechnic University
Hong Kong, Hong Kong, Hong Kong, 000000