Status:
RECRUITING
Unveiling the Neural Mechanisms of 5-HT7 in Sleep Apnea Induced by Arousal Dysregulation
Lead Sponsor:
Beijing Tsinghua Chang Gung Hospital
Conditions:
Obstructive Sleep Apnea
Eligibility:
All Genders
20-60 years
Brief Summary
Obstructive sleep apnea (OSA), recognized as a highly prevalent sleep breathing disorder with severe complications, features a complex etiology. Poor understanding of disease pathogenesis limits the o...
Detailed Description
The study consists of two parts: The first part is a cross-sectional study comparing the differences in arousal threshold, loop gain, and the brain network structure and functional connectivity of the...
Eligibility Criteria
Inclusion
- OSA Patients:
- Age between 20 and 60 years.
- Symptoms of sleep snoring and daytime sleepiness.
- Confirmed diagnosis of OSA following overnight sleep monitoring.
- Simple Snorers:
- Age between 20 and 60 years.
- Symptoms of sleep snoring.
- Overnight sleep monitoring indicates not meeting the OSA diagnosis.
- Healthy Controls:
- Age between 20 and 60 years.
- No symptoms of sleep snoring.
- Overnight sleep monitoring rules out the diagnosis of OSA.
Exclusion
- Presence of severe pulmonary, neurological, or cardiovascular complications.
- History of long-term non-invasive positive pressure ventilation treatment (more than 3 months) or upper airway surgery.
- Sleep-disordered breathing due to special etiologies such as hypothyroidism, acromegaly, vocal cord paralysis, etc.
- Presence of severe mental illness, long-term alcohol abuse, or a history of prolonged use of sedative-hypnotic drugs.
- Central sleep apnea predominant sleep disorders due to various causes.
- Severe craniofacial deformities, myasthenia gravis, or other known myopathic histories.
- Patients with peripheral neuropathy caused by diabetes, autoimmune diseases, etc.
- Patients with comorbid insomnia, anxiety, depression, or other types of sleep disorders.
Key Trial Info
Start Date :
August 30 2024
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 31 2026
Estimated Enrollment :
140 Patients enrolled
Trial Details
Trial ID
NCT06608888
Start Date
August 30 2024
End Date
December 31 2026
Last Update
September 26 2024
Active Locations (1)
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1
No. 168 Litang Road, Changping District
Beijing, Beijing Municipality, China, 100028