Status:
RECRUITING
Effects of 60-day-6° Head-down Bed Rest on Cartilage and Function of the Knee Joint
Lead Sponsor:
Peking University Third Hospital
Conditions:
Cartilage Degeneration
Weightlessness
Eligibility:
MALE
25-50 years
Phase:
NA
Brief Summary
Objective: To investigate the effects of long-term simulated unloading in bed on articular cartilage quality based on functional magnetic resonance imaging (FMRI) and Knee joint function.
Detailed Description
A total of 26 subjects were recruited for a 60-day period of head-down bed rest (HDBR). The bed rest position is a 6° downward tilt of the head, and all daily activities are performed in this position...
Eligibility Criteria
Inclusion
- (1) male; (2) age 25-50 years old; (3) height between 160-175 cm, weight ≥50kg, and BMI between 18.5-26 kg/m²; (4) good general health status.
Exclusion
- (1) history of alcoholism; (2) smoking ≥5 cigarettes/day in the 3 months before the test; (3) drug dependence or use of medications affecting bone metabolism within 2 weeks before screening; (4) presence of metal implants, severe vertigo, or severe snoring.
Key Trial Info
Start Date :
September 10 2023
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
November 15 2024
Estimated Enrollment :
26 Patients enrolled
Trial Details
Trial ID
NCT06612372
Start Date
September 10 2023
End Date
November 15 2024
Last Update
September 25 2024
Active Locations (1)
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1
Peking University Third Hospital
Beijing, China