Status:
COMPLETED
Optimization of Time Parameters of Priming iTBS for Poststroke Motor Rehabilitation
Lead Sponsor:
The Hong Kong Polytechnic University
Conditions:
Stroke
Stroke Rehabilitation
Eligibility:
All Genders
18-75 years
Phase:
NA
Brief Summary
The goal of this clinical trial is to identify the effect of different time intervals between continuous theta burst stimulation (cTBS) and intermittent theta burst stimulation(iTBS), on top of a stan...
Detailed Description
Delivering Intermittent theta burst stimulation (iTBS) primed with continuous theta burst stimulation (cTBS) to the primary motor cortex (M1) may enhance the facilitatory effect of iTBS on the stimula...
Eligibility Criteria
Inclusion
- diagnosis of hemorrhagic or ischemic stroke using computed tomography (CT) or magnetic resonance imaging (MRI).
- the first-ever stroke with unilateral hemiplegia.
- 18-75 years old.
- chronic stroke ( ≥ 6 months).
- residual hemiparetic upper limb functional level in the Functional Test for the Hemiplegic Upper Extremity (FTHUE-HK) ≥ 2.
- can understand and read Chinese.
- signed informed consent.
Exclusion
- diagnosis of any clinically significant or unstable medical disorder.
- any contraindications to TMS based on the TMS safety guidelines (Rossi, Hallett, Rossini, \& Pascual-Leone, 2011).
- inability to follow treatment instructions due to severe cognitive (using the Hong Kong version of the Montreal Cognitive Assessment (MoCA-HK) \< 22/30) and communication deficiency.
- extreme spasticity over the hemiparetic upper limb (Modified Ashworth Score\>2) or severe pain that hindered movement.
- a history of neurological or psychiatric disease excluding stroke, or current use of psychoactive medication (sedatives, antipsychotics, antidepressants, etc.).
Key Trial Info
Start Date :
October 1 2024
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2025
Estimated Enrollment :
62 Patients enrolled
Trial Details
Trial ID
NCT06612437
Start Date
October 1 2024
End Date
December 1 2025
Last Update
January 6 2026
Active Locations (2)
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1
The Hong Kong Polytechnic University
Hong Kong, HK, Hong Kong
2
The Hong Kong Polytechnic University
Hong Kong, Hong Kong