Status:
NOT_YET_RECRUITING
Zn Supplementation in HIV Immunological Non Responders
Lead Sponsor:
Parc de Salut Mar
Collaborating Sponsors:
Hospital de Sabadell
Conditions:
HIV
Zinc Status
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
Zinc is an essential micronutrient crucial for the normal functioning of the human immune system. Zinc deficiency impairs immune function and increases infection risk, especially in vulnerable populat...
Detailed Description
Studies of people living with HIV show that although antiretroviral treatments (ART) decreases inflammation, a number of inflammatory markers remain persistently elevated and this chronic inflammation...
Eligibility Criteria
Inclusion
- confirmed HIV infection;
- 18 years or older
- Serum zinc levels less than 150ug/dl (normal range considered 75-150 ug/dl)
- HIV-1 infection on stable ART for at least 3 months with cumulative ART duration of at least 6 months
- Undetectable (less than 50copies/ml) persistently (isolated transient increases in viremia of less than 1000 copies/ml will be accepted)
- Persistent less than 500CD4+ T-cells/mm3 at enrolment or an increase of less than 80 cells/mm3 after one year of viral undetectability
Exclusion
- Pregnancy
- Lactation
- Active infectious or inflammatory condition
- Uncontrolled diabetes
- Serum Zinc levels more than 150ug/dl
Key Trial Info
Start Date :
January 2 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2026
Estimated Enrollment :
120 Patients enrolled
Trial Details
Trial ID
NCT06612554
Start Date
January 2 2025
End Date
December 1 2026
Last Update
September 26 2024
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