Status:
NOT_YET_RECRUITING
Neuromodulation and FMRI in Neurodegenerative Diseases Study
Lead Sponsor:
Sunnybrook Health Sciences Centre
Conditions:
Mild Cognitive Impairment
Traumatic Brain Injury
Eligibility:
All Genders
25+ years
Phase:
NA
Brief Summary
In addition to neuronal loss, dysfunction in brain network connectivity has been identified as a correlate of cognitive deficits in neurodegenerative and post-traumatic brain injury states. Transcrani...
Detailed Description
The participants will first be scanned on a 3T MRI system (at Sunnybrook Health Sciences Centre) using a multi-channel receive head coil. The MRI protocol will comprise a T1-weighted structural scan ...
Eligibility Criteria
Inclusion
- Be at least 25 years of age;
- Have no contraindications to MRI
- Have received 8 or more years of formal education
- Be fluent in English
- Cohort a. must be followed at Sunnybrook Health Sciences Center
- Cohort a:
- Have been diagnosed with a suspected neurodegenerative disorder or traumatic brain injury (TBI) with memory deficits impacting functional status
- In case of TBI, cognitive impairment has persisted at least three months post-injury
- Received score of 16 or lower on the Mini Mental State Examination (MMSE)
- Cohort b:
- Have no prior diagnosis of a neurodegenerative disorder or post-traumatic brain injury cognitive deficits
- Be experiencing healthy aging and be age and sex matched to Cohort a.
Exclusion
- Have any contraindications to MRI
- Be pregnancy
- Have any major comorbid medical conditions (as determined by investigators - e.g., comorbid neurological diseases, uncontrolled hypertension or diabetes, malignancy) or major comorbid psychiatric conditions (as determined by investigators - e.g., schizophrenia or bipolar disorder)
Key Trial Info
Start Date :
September 1 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2027
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT06873750
Start Date
September 1 2025
End Date
December 1 2027
Last Update
March 13 2025
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