Status:
NOT_YET_RECRUITING
Investigating the Combined Effects of Intermittent Hypoxia and Exercise on Cognitive and Cerebral Function in Middle-Aged Adults
Lead Sponsor:
Ayoub Boulares
Collaborating Sponsors:
University of Poitiers
Laboratory MOVE, Faculty of Sport Sciences, University of Poitiers, France
Conditions:
Cognitive Ability, General
Brain Health
Eligibility:
All Genders
50-65 years
Phase:
NA
Brief Summary
This study investigates whether intermittent hypoxia (IH) and physical activity (PA), either alone or in combination (simultaneously or sequentially), can improve cognitive function and brain health i...
Detailed Description
Rapid demographic aging worldwide is driving a surge in age-related conditions, including neurodegenerative diseases and cognitive disorders. Projections estimate that the number of people living with...
Eligibility Criteria
Inclusion
- Adults aged 50 to 65 years (male and female)
- Montreal Cognitive Assessment (MoCA) score ≥ 24
- No participation in any structured exercise intervention in the last 6 months
- No exposure to altitudes above 1,500 m in the preceding 3 months
- No chronic kidney, cardiovascular, metabolic, neurological, or orthopedic -disease
- No history of significant respiratory conditions (e.g., asthma, exercise-induced -bronchospasm, dyspnea on exertion)
- No current immunosuppressive treatment (e.g., corticosteroids, antidepressants)
- No history of cancer or arthritis treatments
- No recent blood donation (within the last 2 months)
- Must be covered by a Social Security system or equivalent
- Signed informed consent after receiving clear and transparent study information
- Eligibility confirmed by a medical doctor during the inclusion process
Exclusion
- Active smoking
- Major cardiovascular complications within the last 3 months (e.g., myocardial i-infarction, unstable angina, severe arrhythmias)
- Severe hypertension (≥180 mmHg systolic or ≥110 mmHg diastolic)
- Chronic respiratory insufficiency (e.g., COPD, sleep apnea)
- Diabetes mellitus
- Need for continuous or intermittent oxygen therapy
- Participation in another clinical study at the same time
- Use of corticosteroids or other systemic immunosuppressants
- Any condition compromising safety or study compliance, as determined by the medical team
- Pregnancy or breastfeeding
- Legal or administrative protections (e.g., individuals under guardianship, persons deprived of liberty)
- High baseline physical activity levels (PASE score \>90 indicating moderate-to-intense physical activity)
Key Trial Info
Start Date :
April 1 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 30 2026
Estimated Enrollment :
176 Patients enrolled
Trial Details
Trial ID
NCT06874387
Start Date
April 1 2025
End Date
December 30 2026
Last Update
March 13 2025
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