Status:
ENROLLING_BY_INVITATION
Outcomes of Empiric Antibiotic Therapy Based on Hospital Antibiograms in Organ Transplant Recipients with Bacteraemia
Lead Sponsor:
Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Conditions:
Bacteremia
Transplant Recipient
Eligibility:
All Genders
18+ years
Brief Summary
The purpose of this observational study is to examine how using the hospital cumulative antibiogram to guide empirical antibiotic therapy affects outcomes in patients with bloodstream infections who h...
Detailed Description
Sepsis is a critical condition responsible for more than 750,000 hospitalisations and 200,000 deaths annually in the US. Severe sepsis remains a leading cause of death worldwide, with in-hospital mort...
Eligibility Criteria
Inclusion
- Age ≥ 18 years
- Being SOT
- Monomicrobial bloodstream infection due to Acinetobacter baumannii, Enterobacter spp., Enterococcus faecalis, Enterococcus faecium, Escherichia coli, Klebsiella pneumoniae, Klebsiella other-than pneumoniae, Proteus mirabilis, Pseudomonas aeruginosa, Serratia marcescens, Staphylococcus aureus, Staphylococcus lugdunensis, and Streptococcus spp.
- Hospitalization in Fondazione IRCCS Cà Granda Policlinico of Milano from 2015 to 2023.
Exclusion
- Antibiotic therapy administration outside 48h before-after blood culture collection.
- Polymicrobial bloodstream infections.
Key Trial Info
Start Date :
December 3 2024
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
January 1 2027
Estimated Enrollment :
150 Patients enrolled
Trial Details
Trial ID
NCT06874920
Start Date
December 3 2024
End Date
January 1 2027
Last Update
March 13 2025
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
Milan, Italy