Status:
COMPLETED
Intestinal Flora Differences Between Colorectal Cancer Patients and Healthy Individuals
Lead Sponsor:
Hansung University
Conditions:
Colorectal Cancer; Gut Microbiota Dysbiosis
Eligibility:
All Genders
18-80 years
Brief Summary
This observational case-control study aims to compare the composition of intestinal microbiota between colorectal cancer (CRC) patients and healthy individuals. Fecal samples from 36 CRC patients and ...
Detailed Description
This observational case-control study investigates the compositional differences in intestinal microbiota between individuals diagnosed with colorectal cancer (CRC) and healthy controls. The study enr...
Eligibility Criteria
Inclusion
- Adults (≥18 years) with histopathologically confirmed colorectal cancer (CRC group)
- Archived fecal sample available from time of CRC diagnosis (prior to treatment)
- Complete clinical records including TNM staging (I-III) for CRC patients
- Age- and gender-matched adults without CRC history (control group)
- Archived fecal sample available from routine health check-ups (control group)
Exclusion
- Recent antibiotic or probiotic use (within 3 months)
- History of inflammatory bowel disease
- Incomplete medical records
- For controls: history of colorectal cancer, polyps, or chronic gastrointestinal diseases
- For controls: abnormal colonoscopy or fecal occult blood test within the past year
Key Trial Info
Start Date :
January 1 2021
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
March 1 2025
Estimated Enrollment :
61 Patients enrolled
Trial Details
Trial ID
NCT06875648
Start Date
January 1 2021
End Date
March 1 2025
Last Update
March 18 2025
Active Locations (1)
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1
Central Hospital of Guangdong Provincial Nongken
Zhanjiang, Guangdong, China, 524002