Status:
RECRUITING
Role of MRI Assessment in Fertility Sparing Treatment for Cervical Cancer at Staging and Follow-up and for Identification of Risk Factors for Aggressive Disease.
Lead Sponsor:
Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Conditions:
Cervical Cancer
Eligibility:
FEMALE
18+ years
Brief Summary
The purpose of this study is to investigate the role of MRI, including DWI, in the staging and evaluation of response to fertility sparing treatment, including both primary surgery Protocol FeST-CC V....
Detailed Description
Cervical cancer represents the fourth-most common cancer in women and the leading gynaecologic malignancies, accounting approximately 570,000 cases and 311,000 deaths in 2018 worldwide. In Europe, dur...
Eligibility Criteria
Inclusion
- Patients with cervical cancer FIGO stage up to IB2-IIA1 (T size \< 4 cm) wishing to preserve fertility treated at the Oncological Gynecology Unit of Foundation Policlinico Universitario Agostino Gemelli.
- absence of nodal disease,
- no menopausal status
- wish to preserve fertility
- refusal of radical treatment.
- Patients who had a pre-treatment and post-treatment magnetic resonance imaging.
- Availability of digital MR images and histopathological samples.
Exclusion
- Patients aged under 18 years.
- Neuroendocrine cervical tumours or other rare histology, such as glassy cells or clear cell carcinoma non-HPV related adenocarcinoma.
- ongoing pregnancy at the time of diagnosis.
- Patients without available MR images on digital media or with low quality images.
Key Trial Info
Start Date :
March 1 2024
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 31 2028
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT06877065
Start Date
March 1 2024
End Date
December 31 2028
Last Update
March 14 2025
Active Locations (1)
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1
Advanced Radiology Center- Fondazione Policlinico Universitario A. Gemelli IRCCS
Rome, Italy, 00168