Status:
NOT_YET_RECRUITING
Is the Diurnal Variation in Circulating Levels of Cortisol Reflected in Follicular Fluid of Preovulatory Follicles Close to Ovulation?
Lead Sponsor:
ART Fertility Clinics LLC
Conditions:
Healthy
Eligibility:
FEMALE
18-35 years
Brief Summary
Glucocorticoids and especially cortisol exhibit a pronounced diurnal variation. Levels peak around 8 am and may decrease around two to three times during the day reaching a nadir during the evening an...
Eligibility Criteria
Inclusion
- Indication for IVF / ICSI - treatment
- Age ≥ 18 years and ≤ 35 years
- Body weight: 19 - 29 kg/m2
- Ovarian reserve parameters in the adequate age - range, determined by Anti-Muellerian-Hormone (AMH) and Antral Follicle Count (AFC) (Shebl 2011, Hamdine 2015)
- Regular cycle (25-35 days)
Exclusion
- Age \< 18 years and \> 35 years
- Body weight \< 60 kg and \> 90 kg
- Ovarian reserve parameters outside the adequate age - range, determined by Anti-Muellerian-Hormone (AMH) and Antral Follicle Count (AFC) (Shebl 2011, Hamdine 2015)
- Proven poor responder in preceding IVF-treatment-cycle, according to the Bologna criteria: at least two of the following three features must be present:
- (i) Advanced maternal age (≥40 years) or any other risk factor for POR (poor ovarian response) (ii) A previous POR (≤3 oocytes with a conventional stimulation protocol) (iii) An abnormal ovarian reserve test (i.e. AFC \< 5-7 follicles or AMH \< 0.5 -1.1 ng/ml)
- Two episodes of POR after maximal stimulation are sufficient to define a patient as a poor responder in the absence of advanced maternal age or abnormal ORT
- Diagnosis of polycystic ovarian syndrome (PCOS), according to Rotterdam criteria
- Endometriosis stage 3 or 4 AFS (American Fertility Society)
- Irregular cycle (\< 25 days and \> 35 days)
- Treatment with GnRH-analogues during the previous 6 months
- Intake of contraceptive pill (OCP) or any hormonal treatment during the last 3 months
Key Trial Info
Start Date :
December 30 2025
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 1 2026
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT06877429
Start Date
December 30 2025
End Date
December 1 2026
Last Update
October 2 2025
Active Locations (1)
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1
ART Fertility Clinics LLC
Abu Dhabi, United Arab Emirates