Status:
RECRUITING
Effect of Snacks on Aging
Lead Sponsor:
University of California, Los Angeles
Collaborating Sponsors:
American Pecan Promotion Board
Conditions:
Aging
Eligibility:
FEMALE
55-75 years
Phase:
NA
Brief Summary
The purpose of this study is to determine if daily consumption of 2 oz of pecans compared to 3.5 oz pretzel snacks for 12 weeks will 1) contribute to the body's ability to protect itself from oxidativ...
Detailed Description
Oxidative stress plays a significant role in the aging process. Antioxidant potential of tree nuts, including pecans, has been previously reported. However, very few studies have evaluated the antioxi...
Eligibility Criteria
Inclusion
- Female
- Generally healthy
- Aged 55-75 years
- BMI 18.5-34.9 kg/m2
- Fitzpatrick Skin type II-IV
- Consume a typical Western diet (low in polyphenols-rich foods and fiber)
- Willing to maintain habitual dietary and exercise patterns for the study duration
- Willing to maintain normal skin care products and pattern for the duration of the study
- Willing to come to study visits without any makeup and skin products on
- Subjects must read and sign the Institutional Review Board-approved written informed consent prior to the initiation of any study specific procedures or enrollment. A subject will be excluded for any condition that might compromise the ability to give truly informed consent.
Exclusion
- Vegetarian/vegan
- Known nut allergy
- Skin-related prescription medication, supplements or non-prescription cosmeceutical agents
- Initiation of topical or oral prescription steroids and/or anti-inflammatory medications within 30 days prior to study enrollment
- Excessive exposure to either natural or artificial sunlight
- Screening laboratory values outside of the normal range that is considered clinically significant for study participation by the investigator
- Documented chronic disease
- Taking medications or supplements known to affect gut microbiota composition (antibiotics within the past 3 months, probiotics, fiber, etc.)
- Taking exogenous hormones (e.g. hormone replacement therapy)
- Recent weight fluctuations (\>10% in the last 6 months)
- Smoker or living with a smoker
- Use of \>20 g of alcohol per day
- Unable or unwilling to comply with the study protocol (including unwillingness to avoid nuts for the whole duration of the study)
- Unable to provide consent
- Pregnancy and/or lactation
Key Trial Info
Start Date :
May 19 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
June 30 2026
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT06879626
Start Date
May 19 2025
End Date
June 30 2026
Last Update
May 28 2025
Active Locations (1)
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1
UCLA Center for Human Nutrition
Los Angeles, California, United States, 90095